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• W2077996870 startingPage "e11017" @default.
• W2077996870 abstract "The importance of growth factors has been recognized for over five decades; however their utilization in medicine has yet to be fully realized. This is because free growth factors have short half-lives in plasma, making direct injection inefficient. Many growth factors are anchored and protected by sulfated glycosaminoglycans in the body. We set out to explore the use of heparin, a well-characterized sulfated glycosaminoglycan, for the controlled release of fibroblast growth factor-2 (FGF-2). Heparin binds a multitude of growth factors and maintains their bioactivity for an extended period of time. We used a biocompatible polycation to precipitate out the [heparin∶FGF-2] complex from neutral buffer to form a release matrix. We can control the release rate of FGF-2 from the resultant matrix by altering the molecular weight of the polycation. The FGF-2 released from the delivery complex maintained its bioactivity and initiated cellular responses that were at least as potent as fresh bolus FGF-2 and fresh heparin stabilized FGF-2. This new delivery platform is not limited to FGF-2 but applicable to the large family of heparin-binding growth factors." @default.
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• W2077996870 date "2010-06-08" @default.
• W2077996870 modified "2023-10-09" @default.
• W2077996870 title "Control Growth Factor Release Using a Self-Assembled [polycation∶heparin] Complex" @default.
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• W2077996870 doi "https://doi.org/10.1371/journal.pone.0011017" @default.
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