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• W2077997072 abstract "Genetic alteration of the p53 gene was examined in tissue specimens of primary gallbladder cancer (GBC) using PCR-single strand conformation polymorphism (SSCP) and direct sequencing analyses. The p53 gene mutation was detected in five of the 16 GBC cases examined (31%). All five cases showed single point mutations; four were mutations resulting in amino acid substitution and the other was one base-pair deletion. Of the five mutations detected, four occurred at evolutionarily conserved regions and the remaining one at a well conserved region among species. Our result is similar to those of previous reports for various human cancers in mutation scattering over four of the five conserved domains." @default.
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• W2077997072 date "1994-01-01" @default.
• W2077997072 modified "2023-10-16" @default.
• W2077997072 title "Mutation of the p53 Gene in Gallbladder Cancer." @default.
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• W2077997072 doi "https://doi.org/10.1620/tjem.172.283" @default.
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