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- W2077997462 abstract "Cytochrome P450s (P450) metabolize arachidonic acid (AA) to hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs). Among these eicosanoids, 20-HETE is formed in a tissue and cell-specific fashion and plays an important role in the regulation of vascular tone in the brain, kidney, heart and splanchnic beds. 20-HETE is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. It depolarizes VSM by blocking the open-state probability of Ca2+-activated K+-channels. Inhibitors of the formation of 20-HETE block the myogenic response of renal and cerebral arterioles in vitro and autoregulation of renal and cerebral blood flow in vivo. The formation of 20-HETE in vascular smooth muscle is stimulated by angiotensin II, endothelin and norepinephrine and is inhibited by nitric oxide (NO). 20-HETE also stimulates mitogenic and angiogenic responses in vitro and in vivo. Changes in the production of 20-HETE have been observed in ischemic cerebrovascular diseases, cardiac ischemia-reperfusion injury, kidney diseases, hypertension, diabetes, uremia, toxemia of pregnancy. The physiological and pathophysiological role of 20-HETE in the regulation of vascular tone are being revealed by the use of newly developed inhibitors of the synthesis of 20-HETE and 20-HETE analogs. The present review summarizes recent findings implicating a critical role for 20-HETE in altering cardiovascular function in a variety of pathological conditions." @default.
- W2077997462 created "2016-06-24" @default.
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- W2077997462 creator A5079406466 @default.
- W2077997462 date "2005-01-01" @default.
- W2077997462 modified "2023-09-23" @default.
- W2077997462 title "Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system" @default.
- W2077997462 cites W1542205514 @default.
- W2077997462 cites W1554504884 @default.
- W2077997462 cites W1619653867 @default.
- W2077997462 cites W1913730804 @default.
- W2077997462 cites W1965545902 @default.
- W2077997462 cites W1967622958 @default.
- W2077997462 cites W1975858064 @default.
- W2077997462 cites W1981699771 @default.
- W2077997462 cites W1991207142 @default.
- W2077997462 cites W1991765235 @default.
- W2077997462 cites W1993709044 @default.
- W2077997462 cites W1994977651 @default.
- W2077997462 cites W1995024660 @default.
- W2077997462 cites W1995142464 @default.
- W2077997462 cites W1998474769 @default.
- W2077997462 cites W1999290511 @default.
- W2077997462 cites W2000038722 @default.
- W2077997462 cites W2016626694 @default.
- W2077997462 cites W2018198144 @default.
- W2077997462 cites W2018724834 @default.
- W2077997462 cites W2019640534 @default.
- W2077997462 cites W2021065154 @default.
- W2077997462 cites W2023033845 @default.
- W2077997462 cites W2024318325 @default.
- W2077997462 cites W2027504703 @default.
- W2077997462 cites W2029070167 @default.
- W2077997462 cites W2040909870 @default.
- W2077997462 cites W2041661025 @default.
- W2077997462 cites W2041781505 @default.
- W2077997462 cites W2047720109 @default.
- W2077997462 cites W2050771112 @default.
- W2077997462 cites W2053837499 @default.
- W2077997462 cites W2061139736 @default.
- W2077997462 cites W2061921569 @default.
- W2077997462 cites W2064411425 @default.
- W2077997462 cites W2064509511 @default.
- W2077997462 cites W2065075784 @default.
- W2077997462 cites W2072648915 @default.
- W2077997462 cites W2074525099 @default.
- W2077997462 cites W2076783344 @default.
- W2077997462 cites W2078048877 @default.
- W2077997462 cites W2079546402 @default.
- W2077997462 cites W2083531486 @default.
- W2077997462 cites W2084234371 @default.
- W2077997462 cites W2089630643 @default.
- W2077997462 cites W2090217538 @default.
- W2077997462 cites W2094794097 @default.
- W2077997462 cites W2097683472 @default.
- W2077997462 cites W2111900924 @default.
- W2077997462 cites W2126393820 @default.
- W2077997462 cites W2130651692 @default.
- W2077997462 cites W2134014661 @default.
- W2077997462 cites W2139918198 @default.
- W2077997462 cites W2140592928 @default.
- W2077997462 cites W2141955630 @default.
- W2077997462 cites W2142243198 @default.
- W2077997462 cites W2144487938 @default.
- W2077997462 cites W2145558701 @default.
- W2077997462 cites W2147111955 @default.
- W2077997462 cites W2148525491 @default.
- W2077997462 cites W2148887017 @default.
- W2077997462 cites W2149413938 @default.
- W2077997462 cites W2154063166 @default.
- W2077997462 cites W2155193020 @default.
- W2077997462 cites W2155683032 @default.
- W2077997462 cites W2156903074 @default.
- W2077997462 cites W2157646577 @default.
- W2077997462 cites W2160369484 @default.
- W2077997462 cites W2161940353 @default.
- W2077997462 cites W2165191737 @default.
- W2077997462 cites W2168349092 @default.
- W2077997462 cites W2168801830 @default.
- W2077997462 cites W2170794217 @default.
- W2077997462 cites W2175563423 @default.
- W2077997462 cites W2228355127 @default.
- W2077997462 cites W2266651864 @default.
- W2077997462 cites W2312616295 @default.
- W2077997462 cites W2397618430 @default.
- W2077997462 cites W2950129564 @default.
- W2077997462 doi "https://doi.org/10.1540/jsmr.41.175" @default.
- W2077997462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16258232" @default.
- W2077997462 hasPublicationYear "2005" @default.
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