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- W2077998568 abstract "Abstract As the leading culprit in cancer incidence for American men, prostate cancer continues to pose significant diagnostic, prognostic, and therapeutic tribulations for clinicians. The vast spectrum of disease behavior warrants better molecular classification to facilitate the development of more robust biomarkers that can identify the more aggressive and clinically significant tumor subtypes that require treatment. The untranslated portion of the human transcriptome, namely noncoding RNAs (ncRNA), is emerging as a key player in cancer initiation and progression and boasts many attractive features for both biomarker and therapeutic research. Genetic linkage studies show that many ncRNAs are located in cancer-associated genomic regions that are frequently deleted or amplified in prostate cancer, whereas aberrant ncRNA expression patterns have well-established links with prostate tumor cell proliferation and survival. The dysregulation of pathways controlled by ncRNAs results in a cascade of multicellular events leading to carcinogenesis and tumor progression. The characterization of RNA species, their functions, and their clinical applicability is a major area of biologic and clinical importance. This review summarizes the growing body of evidence, supporting a pivotal role for ncRNAs in the pathogenesis of prostate cancer. We highlight the most promising ncRNA biomarkers for detection and risk stratification and present the state-of-play for RNA-based personalized medicine in treating the “untreatable” prostate tumors. Clin Cancer Res; 20(1); 35–43. ©2013 AACR." @default.
- W2077998568 created "2016-06-24" @default.
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- W2077998568 date "2014-01-01" @default.
- W2077998568 modified "2023-09-26" @default.
- W2077998568 title "Noncoding RNAs in Prostate Cancer: The Long and the Short of It" @default.
- W2077998568 cites W1963691340 @default.
- W2077998568 cites W1963764316 @default.
- W2077998568 cites W1966434915 @default.
- W2077998568 cites W1966714489 @default.
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- W2077998568 cites W1973330264 @default.
- W2077998568 cites W1974558929 @default.
- W2077998568 cites W1976324983 @default.
- W2077998568 cites W1978227858 @default.
- W2077998568 cites W1983428971 @default.
- W2077998568 cites W1983453097 @default.
- W2077998568 cites W1997367235 @default.
- W2077998568 cites W2008557144 @default.
- W2077998568 cites W2017426710 @default.
- W2077998568 cites W2022667041 @default.
- W2077998568 cites W2026570544 @default.
- W2077998568 cites W2030331235 @default.
- W2077998568 cites W2032923154 @default.
- W2077998568 cites W2035937780 @default.
- W2077998568 cites W2046233258 @default.
- W2077998568 cites W2046379971 @default.
- W2077998568 cites W2048577371 @default.
- W2077998568 cites W2048603557 @default.
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- W2077998568 cites W2062786725 @default.
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- W2077998568 cites W2066239958 @default.
- W2077998568 cites W2070765029 @default.
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- W2077998568 cites W2087616533 @default.
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- W2077998568 cites W2092979611 @default.
- W2077998568 cites W2093557716 @default.
- W2077998568 cites W2094171848 @default.
- W2077998568 cites W2095307498 @default.
- W2077998568 cites W2095761465 @default.
- W2077998568 cites W2102304447 @default.
- W2077998568 cites W2112001233 @default.
- W2077998568 cites W2113645544 @default.
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- W2077998568 cites W2138090961 @default.
- W2077998568 cites W2139966272 @default.
- W2077998568 cites W2144149602 @default.
- W2077998568 cites W2145387574 @default.
- W2077998568 cites W2146648170 @default.
- W2077998568 cites W2147900600 @default.
- W2077998568 cites W2148780593 @default.
- W2077998568 cites W2150337216 @default.
- W2077998568 cites W2156438249 @default.
- W2077998568 cites W2160276170 @default.
- W2077998568 cites W2160968516 @default.
- W2077998568 cites W2168138611 @default.
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- W2077998568 cites W2170685293 @default.
- W2077998568 cites W2316122628 @default.
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- W2077998568 doi "https://doi.org/10.1158/1078-0432.ccr-13-1989" @default.
- W2077998568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24146262" @default.
- W2077998568 hasPublicationYear "2014" @default.
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