Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077998909> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W2077998909 endingPage "208" @default.
- W2077998909 startingPage "201" @default.
- W2077998909 abstract "Cytokines are proteins that play an important role in the control of different diseases but, produced in excess or in the wrong site, they can cause pathological changes. The existence of the basic effector subsets of proinflammatory and anti-inflammatory cytokines is now well accepted, and is being used to plan therapeutic strategies for inflammatory and autoimmune disorders. Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS). It is considered as an autoimmune disease associated with immune activity directed against CNS antigens. Immune mechanisms involving proinflammatory cytokines are believed to play an important role in the pathogenesis of MS. Thus, immunosuppression and immunomodualtion have become a focus of therapeutic strategies in MS. Recombinant interferon-beta (IFN-β) has been introduced as a drug and was considered to be the first breakthrough in the treatment of multiple sclerosis. Placebo-controlled, double-blind studies, have demonstrated the efficacy of three different forms of IFN-β administrated by either subcutaneous or intramuscular routes and at different doses in patients with active relapsing-remitting MS (RR-MS). These drugs are IFN-β-1b (Betaferon®) and IFN-β-1a (Avonex® and Rebif®). Different clinical trials demonstrated clear benefits of IFN-β for decreasing relapses and probability of sustained clinical disability progression in patients with RR-MS as assessed by brain magnetic resonance imaging (MRI). Beneficial effects in secondary progressive MS (SP-MS) was also reported. This review addresses the introduction of cytokines as novel and effective therapeutic agents as demonstrated by IFN-β in the treatment for MS. Further evaluation for combination of therapeutic immunomodulatory agents should be considered." @default.
- W2077998909 created "2016-06-24" @default.
- W2077998909 creator A5018715958 @default.
- W2077998909 date "2001-11-01" @default.
- W2077998909 modified "2023-10-02" @default.
- W2077998909 title "Cytokines as Novel Therapeutic Agents for Neuroinflammatory Disorders: A Role for Interferon-β in the Treatment of Multiple Sclerosis" @default.
- W2077998909 doi "https://doi.org/10.2174/1568015013358482" @default.
- W2077998909 hasPublicationYear "2001" @default.
- W2077998909 type Work @default.
- W2077998909 sameAs 2077998909 @default.
- W2077998909 citedByCount "0" @default.
- W2077998909 crossrefType "journal-article" @default.
- W2077998909 hasAuthorship W2077998909A5018715958 @default.
- W2077998909 hasConcept C203014093 @default.
- W2077998909 hasConcept C2776178377 @default.
- W2077998909 hasConcept C2776914184 @default.
- W2077998909 hasConcept C2780640218 @default.
- W2077998909 hasConcept C2994247566 @default.
- W2077998909 hasConcept C71924100 @default.
- W2077998909 hasConcept C87753298 @default.
- W2077998909 hasConceptScore W2077998909C203014093 @default.
- W2077998909 hasConceptScore W2077998909C2776178377 @default.
- W2077998909 hasConceptScore W2077998909C2776914184 @default.
- W2077998909 hasConceptScore W2077998909C2780640218 @default.
- W2077998909 hasConceptScore W2077998909C2994247566 @default.
- W2077998909 hasConceptScore W2077998909C71924100 @default.
- W2077998909 hasConceptScore W2077998909C87753298 @default.
- W2077998909 hasIssue "3" @default.
- W2077998909 hasLocation W20779989091 @default.
- W2077998909 hasOpenAccess W2077998909 @default.
- W2077998909 hasPrimaryLocation W20779989091 @default.
- W2077998909 hasRelatedWork W2037825383 @default.
- W2077998909 hasRelatedWork W2093620882 @default.
- W2077998909 hasRelatedWork W2166816461 @default.
- W2077998909 hasRelatedWork W2509047138 @default.
- W2077998909 hasRelatedWork W2896396308 @default.
- W2077998909 hasRelatedWork W2909276286 @default.
- W2077998909 hasRelatedWork W3099717423 @default.
- W2077998909 hasRelatedWork W3140564387 @default.
- W2077998909 hasRelatedWork W4220731327 @default.
- W2077998909 hasRelatedWork W1205533083 @default.
- W2077998909 hasVolume "1" @default.
- W2077998909 isParatext "false" @default.
- W2077998909 isRetracted "false" @default.
- W2077998909 magId "2077998909" @default.
- W2077998909 workType "article" @default.