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- W2078000145 abstract "COLD and warm auto-agglutinins exist. Both occur in the complete and incomplete forms. They are generally believed to be non-specific. Recently, doubt has been cast on their lack of specificity. I consider that (complete) auto-agglutinins might consist of multiple specific components1–3. Recently, Crawford, Cutbush and Mollison4 have shown that incomplete cold auto-agglutinins present in all human sera have the specificity anti-H. The degree of sensitization of cells of various groups by these antibodies could be arranged in the following descending order, O—A2—B—A1—A1B. Such reactions correspond to the relative amounts of H present in these various cells, O cells containing the most H and A1B cells the least. Further the action of incomplete cold auto-antibodies was inhibited by H substance, and their reactions closely agreed with those of an eel anti-H serum. Absorption of the antibodies in the cold by cells of various groups revealed that if A1B cells are used the amount of antibody absorbed is inappreciable, whereas if O cells are used ability to sensitize group O cells or cells of groups A1 and A2 was completely abolished. These workers consider that the specificity of other non-specific antibodies needs to be re-examined. Davidsohn and Oyamada5 have shown that the warm auto-agglutinins associated with haemolytic anaemias are predominantly specific for the individual's own cells. Weiner et al.6 have demonstrated that such an auto-agglutinin had the specificity anti-e." @default.
- W2078000145 created "2016-06-24" @default.
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- W2078000145 date "1953-10-01" @default.
- W2078000145 modified "2023-09-27" @default.
- W2078000145 title "Specificity of Complete Cold Auto-Agglutinins" @default.
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- W2078000145 doi "https://doi.org/10.1038/172734a0" @default.
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