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• W2078000179 abstract "Apoptosis induced in primary cultures of rat hepatocytes by transforming growth factor beta 1 (TGF-beta 1) was greatly attenuated by inhibitors (5 microM) of calpain I and calpain II, respectively. Both inhibitors prevented the TGF-beta-elicited increase of nucleosomal DNA fragments and the occurrence of DNA-breaks in the TUNEL reaction. The detrimental effect of TGF-beta on cell viability measured by the WST-1 test was strongly reduced by calpain inhibitors. Calpain II > I inhibitors suppressed spontaneous DNA cleavage in hepatocytes during culture and prevented the appearance of immunocytochemically visible TGF-beta (APAAP staining), which occurs in untreated parenchymal cell cultures. The data show that inactivation of calpains attenuates both the TGF-beta-elicited and the spontaneous apoptosis of cultured hepatocytes; the latter effect is likely due to the suppression of endogenous TGF-beta activation. It is suggested that calpains participate in these processes." @default.
• W2078000179 created "2016-06-24" @default.
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• W2078000179 date "1997-02-01" @default.
• W2078000179 modified "2023-09-26" @default.
• W2078000179 title "Attenuation of TGF-β-Induced Apoptosis in Primary Cultures of Hepatocytes by Calpain Inhibitors" @default.
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• W2078000179 doi "https://doi.org/10.1006/bbrc.1996.5777" @default.
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