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• W2078005143 abstract "Focal cortical dysplasia (FCD) are associated with neurological disorders and cognitive impairments in humans. Molecular layer ectopia, clusters of misplaced cells in layer I of the neocortex, have been identified in patients with developmental dyslexia and psychomotor retardation. Mouse models of this developmental disorder display behavioral impairments and increased seizure susceptibility. Although there is a correlation between cortical malformations and neurological dysfunction, little is known about the morphological and physiological properties of cells within cortical malformations. In the present study we used electrophysiological and immunocytochemical analyses to examine the distribution of neuronal and non-neuronal cell types within and surrounding layer I neocortical ectopia in NXSMD/EiJ mice. We show that cells within ectopia have membrane properties of both pyramidal and a variety of non-pyramidal cell types, including fast-spiking cells. Immunocytochemical analysis for different interneuronal subtypes demonstrates that ectopia contain nonpyramidal cells immunoreactive for calbindin-D28K (CALB), parvalbumin (PARV), and calretinin (CR). Ectopia also contains astrocytes, positive for glial fibrillary acidic protein (GFAP) and oligodendrocyte precursor cells positive for NG2 proteoglycan (NG2). Lastly, we provide electrophysiological and morphological evidence to demonstrate that cells within ectopia receive input from cells within layers I, upper and deeper II/III, and V and provide outputs to cells within deep layer II/III and layer V, but not layers I and upper II/III. These results indicate that ectopia contain cells of different lineages with diverse morphological and physiological properties, and appear to cause disruptions in local cortical circuitry." @default.
• W2078005143 created "2016-06-24" @default.
• W2078005143 creator A5029635755 @default.
• W2078005143 date "2011-03-01" @default.
• W2078005143 modified "2023-09-26" @default.
• W2078005143 title "Layer I neocortical ectopia: Cellular organization and local cortical circuitry" @default.
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• W2078005143 doi "https://doi.org/10.1016/j.brainres.2011.01.040" @default.
• W2078005143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3082941" @default.
• W2078005143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21256119" @default.
• W2078005143 hasPublicationYear "2011" @default.
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