Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078005404> ?p ?o ?g. }
- W2078005404 endingPage "151" @default.
- W2078005404 startingPage "143" @default.
- W2078005404 abstract "Serum and intrahepatic hepatitis C virus (HCV) RNA were measured in 37 HIV-HCV co-infected patients with controlled human immunodeficiency virus (HIV) infection and correlated with clinical, biological, and histological parameters. Thirty-seven interferon-naive patients underwent liver biopsy. HCV-induced activity (A) and fibrosis (F) were evaluated with METAVIR score. The 37 patients included had HIV plasma loads < 10,000 copies/ml, CD4(+) count > 250/microl. All the patients but two were receiving antiretroviral treatment. Liver tissue and sera were used for measurement of HCV RNA by the Cobas Amplicor HCV Monitor. All patients had serum and liver HCV RNA, and both levels were correlated (r = 0.47; P = 0.003). Intrahepatic HCV load did not depend on age, sex, duration of HCV infection, CD4(+), HCV genotype, or fibrosis. AST levels correlated with intrahepatic HCV load (r = 0.52; P = 0.001). Patients with METAVIR A1/A2 had significantly lower levels of liver HCV-RNA than were found in patients with METAVIR A3 (P = 0.026). Highly active antiretroviral therapy (HAART) including protease inhibitors(PI)-treated patients had significantly lower intrahepatic HCV load (P = 0.04). A weak but significant correlation between serum and liver HCV RNA was found. The amount of hepatic HCV RNA was correlated with AST levels, histological activity, but not with HCV genotype or fibrosis. The immune improvement associated with PI regimens could help reduce HCV load, supporting a protective effect of PI-induced immune restoration." @default.
- W2078005404 created "2016-06-24" @default.
- W2078005404 creator A5013122234 @default.
- W2078005404 creator A5024716669 @default.
- W2078005404 creator A5032943621 @default.
- W2078005404 creator A5037531644 @default.
- W2078005404 creator A5038739562 @default.
- W2078005404 creator A5040110442 @default.
- W2078005404 creator A5043340550 @default.
- W2078005404 creator A5043787553 @default.
- W2078005404 creator A5052635966 @default.
- W2078005404 creator A5060255359 @default.
- W2078005404 creator A5062239019 @default.
- W2078005404 creator A5066985655 @default.
- W2078005404 creator A5078695748 @default.
- W2078005404 creator A5081460531 @default.
- W2078005404 date "2002-04-03" @default.
- W2078005404 modified "2023-10-18" @default.
- W2078005404 title "Intrahepatic HCV RNA loads in 37 HIV-HCV co-infected patients with controlled HIV infection" @default.
- W2078005404 cites W1598503360 @default.
- W2078005404 cites W1616137300 @default.
- W2078005404 cites W1766512274 @default.
- W2078005404 cites W1952952161 @default.
- W2078005404 cites W1963719742 @default.
- W2078005404 cites W1964082735 @default.
- W2078005404 cites W1973336116 @default.
- W2078005404 cites W1976437521 @default.
- W2078005404 cites W1993981249 @default.
- W2078005404 cites W1997312284 @default.
- W2078005404 cites W2004379480 @default.
- W2078005404 cites W2006099253 @default.
- W2078005404 cites W2011051021 @default.
- W2078005404 cites W2012895472 @default.
- W2078005404 cites W2014186485 @default.
- W2078005404 cites W2015795623 @default.
- W2078005404 cites W2017835467 @default.
- W2078005404 cites W2019798157 @default.
- W2078005404 cites W2023441705 @default.
- W2078005404 cites W2036313720 @default.
- W2078005404 cites W2045839792 @default.
- W2078005404 cites W2046150483 @default.
- W2078005404 cites W2051126700 @default.
- W2078005404 cites W2055097012 @default.
- W2078005404 cites W2062699594 @default.
- W2078005404 cites W2063993043 @default.
- W2078005404 cites W2066996703 @default.
- W2078005404 cites W2067312304 @default.
- W2078005404 cites W2094174828 @default.
- W2078005404 cites W2114376411 @default.
- W2078005404 cites W2120287285 @default.
- W2078005404 cites W2120852584 @default.
- W2078005404 cites W2123111996 @default.
- W2078005404 cites W2123135658 @default.
- W2078005404 cites W2127900551 @default.
- W2078005404 cites W2129348532 @default.
- W2078005404 cites W2131196141 @default.
- W2078005404 cites W2145551895 @default.
- W2078005404 cites W2156457356 @default.
- W2078005404 cites W2157817548 @default.
- W2078005404 cites W2162325574 @default.
- W2078005404 cites W2168493740 @default.
- W2078005404 cites W2170737249 @default.
- W2078005404 cites W2206605314 @default.
- W2078005404 cites W2329393410 @default.
- W2078005404 cites W2329529383 @default.
- W2078005404 cites W2339219218 @default.
- W2078005404 cites W4244625703 @default.
- W2078005404 cites W4249810852 @default.
- W2078005404 cites W4250733919 @default.
- W2078005404 cites W4251758068 @default.
- W2078005404 cites W74297457 @default.
- W2078005404 doi "https://doi.org/10.1002/jmv.2203" @default.
- W2078005404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11992575" @default.
- W2078005404 hasPublicationYear "2002" @default.
- W2078005404 type Work @default.
- W2078005404 sameAs 2078005404 @default.
- W2078005404 citedByCount "33" @default.
- W2078005404 countsByYear W20780054042012 @default.
- W2078005404 countsByYear W20780054042016 @default.
- W2078005404 crossrefType "journal-article" @default.
- W2078005404 hasAuthorship W2078005404A5013122234 @default.
- W2078005404 hasAuthorship W2078005404A5024716669 @default.
- W2078005404 hasAuthorship W2078005404A5032943621 @default.
- W2078005404 hasAuthorship W2078005404A5037531644 @default.
- W2078005404 hasAuthorship W2078005404A5038739562 @default.
- W2078005404 hasAuthorship W2078005404A5040110442 @default.
- W2078005404 hasAuthorship W2078005404A5043340550 @default.
- W2078005404 hasAuthorship W2078005404A5043787553 @default.
- W2078005404 hasAuthorship W2078005404A5052635966 @default.
- W2078005404 hasAuthorship W2078005404A5060255359 @default.
- W2078005404 hasAuthorship W2078005404A5062239019 @default.
- W2078005404 hasAuthorship W2078005404A5066985655 @default.
- W2078005404 hasAuthorship W2078005404A5078695748 @default.
- W2078005404 hasAuthorship W2078005404A5081460531 @default.
- W2078005404 hasConcept C126322002 @default.
- W2078005404 hasConcept C142462285 @default.
- W2078005404 hasConcept C159047783 @default.
- W2078005404 hasConcept C203014093 @default.