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- W2078005642 abstract "Hippocampal population bursts (sharp wave-ripples) occur during rest and slow-wave sleep and are thought to be important for memory consolidation. The cellular mechanisms involved are incompletely understood. Here we investigated the cellular mechanisms underlying the initiation of sharp waves using a hippocampal slice model. To this end, we used a combination of field recordings with planar multielectrode arrays and whole-cell patch-clamp recordings of individual anatomically identified pyramidal neurons and interneurons. We found that GABA(A) receptor-mediated inhibition is necessary for sharp wave generation. Moreover, the activity of individual perisomatic-targeting interneurons can both suppress, and subsequently enhance, the local generation of sharp waves. Finally, we show that this is achieved by the tight control of local excitation and inhibition by perisomatic-targeting interneurons. These results suggest that perisomatic-targeting interneurons assist in selecting the subset of pyramidal neurons that initiate each hippocampal sharp wave-ripple." @default.
- W2078005642 created "2016-06-24" @default.
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- W2078005642 date "2010-04-28" @default.
- W2078005642 modified "2023-10-02" @default.
- W2078005642 title "Priming of Hippocampal Population Bursts by Individual Perisomatic-Targeting Interneurons" @default.
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- W2078005642 doi "https://doi.org/10.1523/jneurosci.3962-09.2010" @default.
- W2078005642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3763476" @default.
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