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- W2078006332 abstract "The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin–catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. We show that short hairpin RNA-mediated knockdown of erbin and knockdown or genetic ablation of δ-catenin severely impaired dendritic morphogenesis in hippocampal neurons. Simultaneous loss of erbin and δ-catenin does not enhance severity of this phenotype. The dendritic phenotype observed after erbin depletion is rescued by overexpression of δ-catenin and requires a domain in δ-catenin that has been shown to regulate dendritic branching. Knockdown of δ-catenin cannot be rescued by overexpression of erbin, indicating that erbin is upstream of δ-catenin. δ-Catenin-null neurons have no alterations in global levels of active Rac1/RhoA. Knockdown of erbin results in alterations in localization of δ-catenin. These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of δ-catenin." @default.
- W2078006332 created "2016-06-24" @default.
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- W2078006332 date "2008-07-09" @default.
- W2078006332 modified "2023-10-17" @default.
- W2078006332 title "Erbin Controls Dendritic Morphogenesis by Regulating Localization of δ-Catenin" @default.
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- W2078006332 doi "https://doi.org/10.1523/jneurosci.0451-08.2008" @default.
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