Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078006705> ?p ?o ?g. }
- W2078006705 endingPage "262" @default.
- W2078006705 startingPage "257" @default.
- W2078006705 abstract "Glypican-3 (GPC3) encodes a cell-surface heparan- sulfate proteoglycan and its expression is frequently silenced in ovarian cancer, mesotheliomas, and breast cancer cell lines and ectopic expression of GPC3 inhibited the growth of these cells, suggesting that GPC3 plays a negative role in cell proliferation. In contrast, up-regulation of GPC3 is often observed in hepatoma, neuroblastoma, and Wilms' tumor. Whether GPC3 plays the same growth inhibitory role in these tumors remains to be studied. Here we report that antisense-mediated knockdown of GPC3 in the HepG2 hepatoma cells significantly promotes the growth of hepatoma cells. In addition, we show that this growth promotion is independent of insulin-like growth factor 2 (IGF2) signaling. Our data suggest that GPC3 plays a growth-suppressing role in hepatoma and provide cell biological evidence inconsistent with the hypothesis that GPC3 acts as a growth suppressor by downregulating IGF2." @default.
- W2078006705 created "2016-06-24" @default.
- W2078006705 creator A5015079431 @default.
- W2078006705 creator A5024382477 @default.
- W2078006705 creator A5027756452 @default.
- W2078006705 creator A5076324929 @default.
- W2078006705 creator A5084320255 @default.
- W2078006705 date "2003-08-01" @default.
- W2078006705 modified "2023-10-18" @default.
- W2078006705 title "Growth promotion of HepG2 hepatoma cells by antisense-mediated knockdown of glypican-3 is independent of insulin-like growth factor 2 signaling" @default.
- W2078006705 cites W1577566545 @default.
- W2078006705 cites W1768241097 @default.
- W2078006705 cites W1965612162 @default.
- W2078006705 cites W1972462861 @default.
- W2078006705 cites W1977415499 @default.
- W2078006705 cites W1989709392 @default.
- W2078006705 cites W2008099291 @default.
- W2078006705 cites W2009572702 @default.
- W2078006705 cites W2016717834 @default.
- W2078006705 cites W2019649871 @default.
- W2078006705 cites W2039481105 @default.
- W2078006705 cites W2043469425 @default.
- W2078006705 cites W2049388096 @default.
- W2078006705 cites W2056621404 @default.
- W2078006705 cites W2059691131 @default.
- W2078006705 cites W2064308078 @default.
- W2078006705 cites W2083871561 @default.
- W2078006705 cites W2130487816 @default.
- W2078006705 cites W2136775778 @default.
- W2078006705 cites W2140956181 @default.
- W2078006705 cites W2142045426 @default.
- W2078006705 cites W2151400827 @default.
- W2078006705 cites W2157715173 @default.
- W2078006705 cites W2159615789 @default.
- W2078006705 cites W2322558359 @default.
- W2078006705 doi "https://doi.org/10.1038/emm.2003.34" @default.
- W2078006705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14508064" @default.
- W2078006705 hasPublicationYear "2003" @default.
- W2078006705 type Work @default.
- W2078006705 sameAs 2078006705 @default.
- W2078006705 citedByCount "17" @default.
- W2078006705 countsByYear W20780067052012 @default.
- W2078006705 countsByYear W20780067052013 @default.
- W2078006705 countsByYear W20780067052015 @default.
- W2078006705 countsByYear W20780067052017 @default.
- W2078006705 countsByYear W20780067052018 @default.
- W2078006705 crossrefType "journal-article" @default.
- W2078006705 hasAuthorship W2078006705A5015079431 @default.
- W2078006705 hasAuthorship W2078006705A5024382477 @default.
- W2078006705 hasAuthorship W2078006705A5027756452 @default.
- W2078006705 hasAuthorship W2078006705A5076324929 @default.
- W2078006705 hasAuthorship W2078006705A5084320255 @default.
- W2078006705 hasBestOaLocation W20780067051 @default.
- W2078006705 hasConcept C170493617 @default.
- W2078006705 hasConcept C173396325 @default.
- W2078006705 hasConcept C185592680 @default.
- W2078006705 hasConcept C2775960820 @default.
- W2078006705 hasConcept C2778019345 @default.
- W2078006705 hasConcept C2779742787 @default.
- W2078006705 hasConcept C502942594 @default.
- W2078006705 hasConcept C54355233 @default.
- W2078006705 hasConcept C62112901 @default.
- W2078006705 hasConcept C74373430 @default.
- W2078006705 hasConcept C81885089 @default.
- W2078006705 hasConcept C86803240 @default.
- W2078006705 hasConcept C95444343 @default.
- W2078006705 hasConcept C97037327 @default.
- W2078006705 hasConceptScore W2078006705C170493617 @default.
- W2078006705 hasConceptScore W2078006705C173396325 @default.
- W2078006705 hasConceptScore W2078006705C185592680 @default.
- W2078006705 hasConceptScore W2078006705C2775960820 @default.
- W2078006705 hasConceptScore W2078006705C2778019345 @default.
- W2078006705 hasConceptScore W2078006705C2779742787 @default.
- W2078006705 hasConceptScore W2078006705C502942594 @default.
- W2078006705 hasConceptScore W2078006705C54355233 @default.
- W2078006705 hasConceptScore W2078006705C62112901 @default.
- W2078006705 hasConceptScore W2078006705C74373430 @default.
- W2078006705 hasConceptScore W2078006705C81885089 @default.
- W2078006705 hasConceptScore W2078006705C86803240 @default.
- W2078006705 hasConceptScore W2078006705C95444343 @default.
- W2078006705 hasConceptScore W2078006705C97037327 @default.
- W2078006705 hasIssue "4" @default.
- W2078006705 hasLocation W20780067051 @default.
- W2078006705 hasLocation W20780067052 @default.
- W2078006705 hasOpenAccess W2078006705 @default.
- W2078006705 hasPrimaryLocation W20780067051 @default.
- W2078006705 hasRelatedWork W1696461650 @default.
- W2078006705 hasRelatedWork W1975781404 @default.
- W2078006705 hasRelatedWork W2020115488 @default.
- W2078006705 hasRelatedWork W2026486999 @default.
- W2078006705 hasRelatedWork W2030758772 @default.
- W2078006705 hasRelatedWork W2359319847 @default.
- W2078006705 hasRelatedWork W2371287223 @default.
- W2078006705 hasRelatedWork W2402532535 @default.
- W2078006705 hasRelatedWork W3101614498 @default.
- W2078006705 hasRelatedWork W3103789129 @default.
- W2078006705 hasVolume "35" @default.
- W2078006705 isParatext "false" @default.