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- W2078007568 abstract "Human platelets play a key role in hemostasis and thrombosis and have recently emerged as key regulators of inflammation. Platelets stored for transfusion produce pro-thrombotic and pro-inflammatory mediators implicated in adverse transfusion reactions. Correspondingly, these mediators are central players in pathological conditions including cardiovascular disease, the major cause of death in diabetics. In view of this, a mass spectrometry based proteomics study was performed on platelets collected from healthy and type-2 diabetics stored for transfusion. Strikingly, our innovative and sensitive proteomic approach identified 122 proteins that were either up- or down-regulated in type-2 diabetics relative to nondiabetic controls and 117 proteins whose abundances changed during a 5-day storage period. Notably, our studies are the first to characterize the proteome of platelets from diabetics before and after storage for transfusion. These identified differences allow us to formulate new hypotheses and experimentation to improve clinical outcomes by targeting “high risk platelets” that render platelet transfusion less effective or even unsafe." @default.
- W2078007568 created "2016-06-24" @default.
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- W2078007568 date "2009-04-07" @default.
- W2078007568 modified "2023-10-15" @default.
- W2078007568 title "Platelet Proteome Changes Associated with Diabetes and during Platelet Storage for Transfusion" @default.
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- W2078007568 doi "https://doi.org/10.1021/pr800885j" @default.
- W2078007568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3017716" @default.
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