FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078010078> ?p ?o ?g. }

• W2078010078 endingPage "561" @default.
• W2078010078 startingPage "549" @default.
• W2078010078 abstract "We have investigated the effects of histamine on the intracellular calcium concentration ([Ca2+]i) of cultured rat cerebellar astrocytes using fura-2-based Ca2+ imaging microscopy. Most of the cells responded to the application of histamine with an increase in [Ca2+]i which was antagonized by the H1 receptor blocker mepyramine. When histamine was applied for several minutes, the majority of the cells displayed a biphasic Ca2+ response consisting of an initial transient peak and a sustained component. In contrast to the initial transient [Ca2+]i response, the sustained, receptor-activated increase in [Ca2+]i was rapidly abolished by chelation of extracellular Ca2+ or addition of Ni2+, Mn2+, Co2+ and Zn2+, but was unaffected by nifedipine, an antagonist of L-type voltage-activated Ca2+ channels. These data indicate that the sustained increase in [Ca2+]i was dependent on Ca2+ influx. When intracellular Ca2+ stores were emptied by prolonged application of histamine in Ca2+-free conditions, Ca2+ re-addition after removal of the agonist did not lead to an 'overshoot' of [Ca2+]i indicative of store-operated Ca2+ influx. However, Ca2+ stores were refilled despite the absence of any substantial change in the fura-2 signal. Depletion of intracellular Ca2+ stores using cyclopiazonic acid in Ca2+-free saline and subsequent re-addition of Ca2+ to the saline resulted in an increase in [Ca2+]i that was significantly enhanced in the presence of histamine. The results suggest that besides capacitative mechanisms, a non-capacitative, voltage-independent pathway is involved in histamine-induced Ca2+ entry into cultured rat cerebellar astrocytes." @default.
• W2078010078 created "2016-06-24" @default.
• W2078010078 creator A5013295033 @default.
• W2078010078 creator A5039967196 @default.
• W2078010078 creator A5089529779 @default.
• W2078010078 date "2000-09-01" @default.
• W2078010078 modified "2023-10-18" @default.
• W2078010078 title "Histamine‐induced calcium entry in rat cerebellar astrocytes: evidence for capacitative and non‐capacitative mechanisms" @default.
• W2078010078 cites W1498257141 @default.
• W2078010078 cites W1502161210 @default.
• W2078010078 cites W1535912510 @default.
• W2078010078 cites W1596294893 @default.
• W2078010078 cites W1973237558 @default.
• W2078010078 cites W1980166477 @default.
• W2078010078 cites W1983030082 @default.
• W2078010078 cites W1995009372 @default.
• W2078010078 cites W1996024251 @default.
• W2078010078 cites W1997439964 @default.
• W2078010078 cites W2002314697 @default.
• W2078010078 cites W2004559721 @default.
• W2078010078 cites W2005946719 @default.
• W2078010078 cites W2008714195 @default.
• W2078010078 cites W2016219644 @default.
• W2078010078 cites W2018533735 @default.
• W2078010078 cites W2019070413 @default.
• W2078010078 cites W2026781911 @default.
• W2078010078 cites W2033023357 @default.
• W2078010078 cites W2036145275 @default.
• W2078010078 cites W2036993777 @default.
• W2078010078 cites W2039530449 @default.
• W2078010078 cites W2039625611 @default.
• W2078010078 cites W2041690080 @default.
• W2078010078 cites W2043202024 @default.
• W2078010078 cites W2048555542 @default.
• W2078010078 cites W2055015343 @default.
• W2078010078 cites W2060859230 @default.
• W2078010078 cites W2065638011 @default.
• W2078010078 cites W2066335466 @default.
• W2078010078 cites W2069075656 @default.
• W2078010078 cites W2070340241 @default.
• W2078010078 cites W2082094899 @default.
• W2078010078 cites W2089089225 @default.
• W2078010078 cites W2090653430 @default.
• W2078010078 cites W2091057443 @default.
• W2078010078 cites W2093364468 @default.
• W2078010078 cites W2095343991 @default.
• W2078010078 cites W2105589721 @default.
• W2078010078 cites W2113708331 @default.
• W2078010078 cites W2114401576 @default.
• W2078010078 cites W2133159119 @default.
• W2078010078 cites W2139443388 @default.
• W2078010078 cites W2140994013 @default.
• W2078010078 cites W2141260882 @default.
• W2078010078 cites W2165697195 @default.
• W2078010078 cites W2169518110 @default.
• W2078010078 cites W2171883189 @default.
• W2078010078 cites W2247803565 @default.
• W2078010078 cites W2268409607 @default.
• W2078010078 cites W2409496334 @default.
• W2078010078 cites W2412999540 @default.
• W2078010078 cites W4246124510 @default.
• W2078010078 cites W4249424055 @default.
• W2078010078 cites W4323053941 @default.
• W2078010078 doi "https://doi.org/10.1111/j.1469-7793.2000.00549.x" @default.
• W2078010078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2270097" @default.
• W2078010078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10990540" @default.
• W2078010078 hasPublicationYear "2000" @default.
• W2078010078 type Work @default.
• W2078010078 sameAs 2078010078 @default.
• W2078010078 citedByCount "54" @default.
• W2078010078 countsByYear W20780100782013 @default.
• W2078010078 countsByYear W20780100782014 @default.
• W2078010078 countsByYear W20780100782015 @default.
• W2078010078 countsByYear W20780100782016 @default.
• W2078010078 countsByYear W20780100782018 @default.
• W2078010078 countsByYear W20780100782019 @default.
• W2078010078 countsByYear W20780100782020 @default.
• W2078010078 countsByYear W20780100782021 @default.
• W2078010078 crossrefType "journal-article" @default.
• W2078010078 hasAuthorship W2078010078A5013295033 @default.
• W2078010078 hasAuthorship W2078010078A5039967196 @default.
• W2078010078 hasAuthorship W2078010078A5089529779 @default.
• W2078010078 hasBestOaLocation W20780100782 @default.
• W2078010078 hasConcept C1122143 @default.
• W2078010078 hasConcept C12554922 @default.
• W2078010078 hasConcept C126322002 @default.
• W2078010078 hasConcept C134018914 @default.
• W2078010078 hasConcept C170493617 @default.
• W2078010078 hasConcept C181080969 @default.
• W2078010078 hasConcept C181199279 @default.
• W2078010078 hasConcept C185592680 @default.
• W2078010078 hasConcept C2776885963 @default.
• W2078010078 hasConcept C2778470358 @default.
• W2078010078 hasConcept C2778938600 @default.
• W2078010078 hasConcept C2779066535 @default.
• W2078010078 hasConcept C2779090179 @default.
• W2078010078 hasConcept C2779996123 @default.
• W2078010078 hasConcept C28406088 @default.

• next