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- W2078010304 abstract "OBJECTIVE: To see the relationship between hyperprolactinemic state and endometrial hyperplasia (EH) and to examine whether the effect of progestin therapy could be augmented by normalization of hyperprolactinemic state. DESIGN: A retrospective analysis, a cohort study, a cross-over study. MATERIALS AND METHODS: To see the population of hyperprolactinemic state (prolactin; over 15 ng/ml) in EH patients, we retrospectively analyzed the data of 283 Japanese women with EH, and measured the serum levels of prolactin in 115 of these patients. We also compared the clinical courses of 22 EH patients with hyperprolactinemic state and 57 EH patients without hyperprolactinemic state, both receiving single progestin therapy. To see the effect of normalization of hyperprolactinemic state on EH, a cohort study of combination therapy with a dopamine agonist, cabergoline, and progestin in 22 EH patients with hyperprolactinemia was performed. RESULTS: The retrospective study revealed that 43/94 of endometrial hyperplasia complex (EHc) and 9/15 of atypical endometrial hyperplasia complex (AEHc) were found to have hyperprolactinemia or hyperprolactinemic state. The backgrounds were similar between EH groups, although slightly different between AEH groups. All of the EHc and AEHc patients with the hyperprolactinemic state had shown recurrence for an average of 15 and 41 months, respectively, while receiving single progestin therapy. On the other hand, with a combined therapy with a dopamine agonist and progestin, 16/17 patients with EHc and 5/5 patients with AEHc showed improvement after an average of 3.9 months (P<0.01, Paired t-test) and 4.4 months (P<0.01, Paired t-test), respectively. This therapy also induced a complete cure for 11/17 patients with EHc and 3/5 patients with AEHc after an average of 4.5 months and 11 months, respectively, while single progestin therapy induced a complete cure for 4/19 of the EHc patients and 0/5 of the AEHc patients with hyperprolactinemia after an average of 12 months. However, a trial of single use of cabergoline in 10 EHc patients with hyperprolactinemia showed lack of any effect, whereas single progestin therapy in these patients yielded some improvement after 20 months. CONCLUSIONS: Our data demonstrated that hyperprolactinemia and hyperprolactinemic state is associated with EH, and that a dopamine agonist has augmentative effects on progestin therapy for EH." @default.
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- W2078010304 date "2008-09-01" @default.
- W2078010304 modified "2023-10-13" @default.
- W2078010304 title "Potential relationship between hyperprolactinemic state and endometrial hyperplasia; augmentative effects of a dopamine agonist on progestin therapy for endometrial hyperplasia" @default.
- W2078010304 doi "https://doi.org/10.1016/j.fertnstert.2008.07.376" @default.
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