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- W2078010825 abstract "This study was designed to determine the clinical implication of expression of progesterone receptor form A (PR-A) and B (PR-B) mRNAs in secondary spreading of gynecologic cancers. Approximately equal expression of PR-A and PR-B mRNAs was designated as type AB and dominant expression of PR-B mRNA as type B. Alteration from type AB to type B in the metastatic cancers occurred in 3/8 cases of uterine endometrial cancers, 2/8 cases of uterine cervical cancers, and 2/8 cases of ovarian cancers. Other cancers revealed type B regardless of primary or metastatic status. Thus, all metastatic cancers studied revealed type B. These results suggest that transcription of PR-A mRNA may be damaged, which might lead to uncontrolled overexpression of PR-B mRNA in metastatic lesion, and that the type B status could reveal a highly malignant phenotype in these three gynecologic cancers." @default.
- W2078010825 created "2016-06-24" @default.
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- W2078010825 date "1997-08-01" @default.
- W2078010825 modified "2023-09-26" @default.
- W2078010825 title "Clinical implication of expression of progesterone receptor form A and B mRNAs in secondary spreading of gynecologic cancers" @default.
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- W2078010825 doi "https://doi.org/10.1016/s0960-0760(97)00057-5" @default.
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