Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078012311> ?p ?o ?g. }
- W2078012311 endingPage "643" @default.
- W2078012311 startingPage "635" @default.
- W2078012311 abstract "HuD is a neuronal specific RNA-binding protein associated with the stabilization of short-lived mRNAs during brain development, nerve regeneration and synaptic plasticity. To investigate the functional significance of this protein in the mature brain, we generated transgenic mice overexpressing HuD in forebrain neurons under the control of the alphaCaMKinII promoter. We have previously shown that one of the targets of HuD, GAP-43 mRNA, was stabilized in neurons in the hippocampus, amygdala and cortex of transgenic mice. Animals from two independent lines expressing different levels of the transgene were subjected to a battery of behavioral tests including contextual fear conditioning and the Morris water maze. Our results show that although HuD is increased after learning and memory, constitutive HuD overexpression impaired the acquisition and retention of both cued and contextual fear and the ability to remember the position of a hidden platform in the Morris water maze. No motor-sensory abnormalities were observed in HuD transgenic mice, suggesting that the poor performance of the mice in these tests reflect a true cognitive impairment. We conclude that posttranscriptional regulation of gene expression by stabilization of specific mRNAs may have to be restricted temporally and spatially for proper acquisition and storage of memories." @default.
- W2078012311 created "2016-06-24" @default.
- W2078012311 creator A5000206266 @default.
- W2078012311 creator A5026184632 @default.
- W2078012311 creator A5031755893 @default.
- W2078012311 creator A5032629851 @default.
- W2078012311 creator A5045363726 @default.
- W2078012311 creator A5062841137 @default.
- W2078012311 date "2007-05-01" @default.
- W2078012311 modified "2023-10-03" @default.
- W2078012311 title "Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD" @default.
- W2078012311 cites W1595801567 @default.
- W2078012311 cites W1908021040 @default.
- W2078012311 cites W1968242863 @default.
- W2078012311 cites W1968946845 @default.
- W2078012311 cites W1979879037 @default.
- W2078012311 cites W1982369409 @default.
- W2078012311 cites W1998938482 @default.
- W2078012311 cites W2001504986 @default.
- W2078012311 cites W2011934699 @default.
- W2078012311 cites W2012560322 @default.
- W2078012311 cites W2012630877 @default.
- W2078012311 cites W2032057219 @default.
- W2078012311 cites W2033746917 @default.
- W2078012311 cites W2035261316 @default.
- W2078012311 cites W2035618537 @default.
- W2078012311 cites W2035869111 @default.
- W2078012311 cites W2040890514 @default.
- W2078012311 cites W2044875682 @default.
- W2078012311 cites W2050733310 @default.
- W2078012311 cites W2052483187 @default.
- W2078012311 cites W2052632013 @default.
- W2078012311 cites W2056200986 @default.
- W2078012311 cites W2063575722 @default.
- W2078012311 cites W2069581520 @default.
- W2078012311 cites W2070365794 @default.
- W2078012311 cites W2070948072 @default.
- W2078012311 cites W2081228528 @default.
- W2078012311 cites W2085709349 @default.
- W2078012311 cites W2093625208 @default.
- W2078012311 cites W2098493979 @default.
- W2078012311 cites W2100214794 @default.
- W2078012311 cites W2101626807 @default.
- W2078012311 cites W2102812687 @default.
- W2078012311 cites W2103239365 @default.
- W2078012311 cites W2106767548 @default.
- W2078012311 cites W2110871941 @default.
- W2078012311 cites W2116047480 @default.
- W2078012311 cites W2131815091 @default.
- W2078012311 cites W2133083344 @default.
- W2078012311 cites W2137769667 @default.
- W2078012311 cites W2141416681 @default.
- W2078012311 cites W2146702633 @default.
- W2078012311 cites W2155765862 @default.
- W2078012311 cites W2158553737 @default.
- W2078012311 cites W2160835256 @default.
- W2078012311 cites W2161629430 @default.
- W2078012311 cites W4214816144 @default.
- W2078012311 doi "https://doi.org/10.1016/j.nlm.2006.11.004" @default.
- W2078012311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17185008" @default.
- W2078012311 hasPublicationYear "2007" @default.
- W2078012311 type Work @default.
- W2078012311 sameAs 2078012311 @default.
- W2078012311 citedByCount "68" @default.
- W2078012311 countsByYear W20780123112012 @default.
- W2078012311 countsByYear W20780123112013 @default.
- W2078012311 countsByYear W20780123112014 @default.
- W2078012311 countsByYear W20780123112015 @default.
- W2078012311 countsByYear W20780123112016 @default.
- W2078012311 countsByYear W20780123112017 @default.
- W2078012311 countsByYear W20780123112018 @default.
- W2078012311 countsByYear W20780123112019 @default.
- W2078012311 countsByYear W20780123112020 @default.
- W2078012311 countsByYear W20780123112021 @default.
- W2078012311 countsByYear W20780123112022 @default.
- W2078012311 countsByYear W20780123112023 @default.
- W2078012311 crossrefType "journal-article" @default.
- W2078012311 hasAuthorship W2078012311A5000206266 @default.
- W2078012311 hasAuthorship W2078012311A5026184632 @default.
- W2078012311 hasAuthorship W2078012311A5031755893 @default.
- W2078012311 hasAuthorship W2078012311A5032629851 @default.
- W2078012311 hasAuthorship W2078012311A5045363726 @default.
- W2078012311 hasAuthorship W2078012311A5062841137 @default.
- W2078012311 hasConcept C102230213 @default.
- W2078012311 hasConcept C104317684 @default.
- W2078012311 hasConcept C12515866 @default.
- W2078012311 hasConcept C141035611 @default.
- W2078012311 hasConcept C15744967 @default.
- W2078012311 hasConcept C16837860 @default.
- W2078012311 hasConcept C169760540 @default.
- W2078012311 hasConcept C2779144063 @default.
- W2078012311 hasConcept C2779715522 @default.
- W2078012311 hasConcept C2781161787 @default.
- W2078012311 hasConcept C44752575 @default.
- W2078012311 hasConcept C529278444 @default.
- W2078012311 hasConcept C55493867 @default.
- W2078012311 hasConcept C86803240 @default.
- W2078012311 hasConceptScore W2078012311C102230213 @default.