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- W2078014276 abstract "Lipid peroxidation was initiated by the addition of either ADP‐complexed Fe 3+ or cumene hydroperoxide to isolated rat hepatocytes and the resultant biochemical and morphological alterations investigated. As previously observed with microsomes, malonaldehyde formation was associated with the inactivation of glucose‐6‐phosphatase. Inhibition of microsomal oxidative drug metabolism was correlated with the release and subsequent inactivation of NADPH‐cytochrome c reductase, whereas cytochrome P ‐450 destruction occurred only in the presence of high concentrations of the organic hydroperoxide which were associated with extensive malonaldehyde formation. Under these conditions there were also marked ultrastructural alterations in the hepatocytes which were not apparent after incubation in the presence of iron (≤ 187 μM Fe 3+ ). The latter treatment was, however, associated with moderate biochemical effects such as glucose‐6‐phosphatase inactivation and increased membrane permeability. The cellular defence system against lipid peroxidation is discussed and it is concluded that the isolated liver cell system provides a valuable tool for the study of lipid peroxidation and its pathological implications." @default.
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- W2078014276 date "1975-11-01" @default.
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- W2078014276 title "The Consequences of Lipid Peroxidation in Isolated Hepatocytes" @default.
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- W2078014276 doi "https://doi.org/10.1111/j.1432-1033.1975.tb02474.x" @default.
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