FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078016443> ?p ?o ?g. }

• W2078016443 endingPage "1764" @default.
• W2078016443 startingPage "1756" @default.
• W2078016443 abstract "Abstract Chronic graft-versus-host disease (GVHD) is the most common cause of poor long-term outcomes after allogeneic bone marrow transplantation (BMT), but the pathophysiology of chronic GVHD still remains poorly understood. We tested the hypothesis that the impaired thymic negative selection of the recipients will permit the emergence of pathogenic T cells that cause chronic GVHD. Lethally irradiated C3H/HeN (H-2k) recipients were reconstituted with T-cell–depleted bone marrow cells from major histocompatibility complex [MHC] class II–deficient (H2-Ab1−/−) B6 (H-2b) mice. These mice developed diseases that showed all of the clinical and histopathological features of human chronic GVHD. Thymectomy prevented chronic GVHD, thus confirming the causal association of the thymus. CD4+ T cells isolated from chronic GVHD mice were primarily donor reactive, and adoptive transfer of CD4+ T cells generated in these mice caused chronic GVHD in C3H/HeN mice in the presence of B6-derived antigen-presenting cells. Our results demonstrate for the first time that T cells that escape from negative thymic selection could cause chronic GVHD after allogeneic BMT. These results also suggest that self-reactivity of donor T cells plays a role in this chronic GVHD, and improvement in the thymic function may have a potential to decrease chronic GVHD." @default.
• W2078016443 created "2016-06-24" @default.
• W2078016443 creator A5007888883 @default.
• W2078016443 creator A5026708269 @default.
• W2078016443 creator A5028484936 @default.
• W2078016443 creator A5028514182 @default.
• W2078016443 creator A5041455800 @default.
• W2078016443 creator A5044544485 @default.
• W2078016443 creator A5079987156 @default.
• W2078016443 date "2006-10-10" @default.
• W2078016443 modified "2023-10-11" @default.
• W2078016443 title "Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease" @default.
• W2078016443 cites W132916333 @default.
• W2078016443 cites W1480177881 @default.
• W2078016443 cites W1490032473 @default.
• W2078016443 cites W1532420525 @default.
• W2078016443 cites W1536570541 @default.
• W2078016443 cites W1540238940 @default.
• W2078016443 cites W1544331058 @default.
• W2078016443 cites W1581519755 @default.
• W2078016443 cites W1621856421 @default.
• W2078016443 cites W1666992241 @default.
• W2078016443 cites W1944382470 @default.
• W2078016443 cites W1963678500 @default.
• W2078016443 cites W1969773034 @default.
• W2078016443 cites W1971103070 @default.
• W2078016443 cites W1985088435 @default.
• W2078016443 cites W1987528721 @default.
• W2078016443 cites W1988200269 @default.
• W2078016443 cites W1992510969 @default.
• W2078016443 cites W1992613163 @default.
• W2078016443 cites W2001457611 @default.
• W2078016443 cites W2014779265 @default.
• W2078016443 cites W2014965697 @default.
• W2078016443 cites W2029487548 @default.
• W2078016443 cites W2031148878 @default.
• W2078016443 cites W2035093315 @default.
• W2078016443 cites W2036872637 @default.
• W2078016443 cites W2037467064 @default.
• W2078016443 cites W2041438140 @default.
• W2078016443 cites W2050755264 @default.
• W2078016443 cites W2054405406 @default.
• W2078016443 cites W2055079427 @default.
• W2078016443 cites W2063491568 @default.
• W2078016443 cites W2073474757 @default.
• W2078016443 cites W2074717114 @default.
• W2078016443 cites W2090810530 @default.
• W2078016443 cites W2093143038 @default.
• W2078016443 cites W2095339383 @default.
• W2078016443 cites W2096648897 @default.
• W2078016443 cites W2099876234 @default.
• W2078016443 cites W2103100707 @default.
• W2078016443 cites W2105239353 @default.
• W2078016443 cites W2105604650 @default.
• W2078016443 cites W2111653667 @default.
• W2078016443 cites W2119624288 @default.
• W2078016443 cites W2121029352 @default.
• W2078016443 cites W2131930650 @default.
• W2078016443 cites W2133104010 @default.
• W2078016443 cites W2137007247 @default.
• W2078016443 cites W2138313532 @default.
• W2078016443 cites W2139184776 @default.
• W2078016443 cites W2146358021 @default.
• W2078016443 cites W2163733482 @default.
• W2078016443 cites W2166338481 @default.
• W2078016443 cites W2398419231 @default.
• W2078016443 cites W2618073389 @default.
• W2078016443 cites W4235172121 @default.
• W2078016443 cites W4244681194 @default.
• W2078016443 cites W4250981201 @default.
• W2078016443 cites W4313347678 @default.
• W2078016443 doi "https://doi.org/10.1182/blood-2006-08-042853" @default.
• W2078016443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17032915" @default.
• W2078016443 hasPublicationYear "2006" @default.
• W2078016443 type Work @default.
• W2078016443 sameAs 2078016443 @default.
• W2078016443 citedByCount "132" @default.
• W2078016443 countsByYear W20780164432012 @default.
• W2078016443 countsByYear W20780164432013 @default.
• W2078016443 countsByYear W20780164432014 @default.
• W2078016443 countsByYear W20780164432015 @default.
• W2078016443 countsByYear W20780164432016 @default.
• W2078016443 countsByYear W20780164432017 @default.
• W2078016443 countsByYear W20780164432018 @default.
• W2078016443 countsByYear W20780164432019 @default.
• W2078016443 countsByYear W20780164432020 @default.
• W2078016443 countsByYear W20780164432021 @default.
• W2078016443 countsByYear W20780164432022 @default.
• W2078016443 countsByYear W20780164432023 @default.
• W2078016443 crossrefType "journal-article" @default.
• W2078016443 hasAuthorship W2078016443A5007888883 @default.
• W2078016443 hasAuthorship W2078016443A5026708269 @default.
• W2078016443 hasAuthorship W2078016443A5028484936 @default.
• W2078016443 hasAuthorship W2078016443A5028514182 @default.
• W2078016443 hasAuthorship W2078016443A5041455800 @default.
• W2078016443 hasAuthorship W2078016443A5044544485 @default.
• W2078016443 hasAuthorship W2078016443A5079987156 @default.
• W2078016443 hasBestOaLocation W20780164431 @default.

• next