FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078016508> ?p ?o ?g. }

• W2078016508 endingPage "756" @default.
• W2078016508 startingPage "744" @default.
• W2078016508 abstract "Preconditioning describes the ischemic stimulus that triggers an endogenous, neuroprotective response that protects the brain during a subsequent severe ischemic injury, a phenomenon known as 'tolerance'. Ischemic tolerance requires new protein synthesis, leads to genomic reprogramming of the brain's response to subsequent ischemia, and is transient. MicroRNAs (miRNAs) regulate posttranscriptional gene expression by exerting direct effects on messenger RNA (mRNA) translation. We examined miRNA expression in mouse cortex in response to preconditioning, ischemic injury, and tolerance. The results of our microarray analysis revealed that miRNA expression is consistently altered within each group, but that preconditioning was the foremost regulator of miRNAs. Our bioinformatic analysis results predicted that preconditioning-regulated miRNAs most prominently target mRNAs that encode transcriptional regulators; methyl-CpG binding protein 2 (MeCP2) was the most prominent target. No studies have linked MeCP2 to preconditioning or tolerance, yet miR-132, which regulates MeCP2 expression, is decreased in preconditioned cortex. Downregulation of miR-132 is consistent with our finding that preconditioning ischemia induces a rapid increase in MeCP2 protein, but not mRNA, in mouse cortex. These studies reveal that ischemic preconditioning regulates expression of miRNAs and their predicted targets in mouse brain cortex, and further suggest that miRNAs and MeCP2 could serve as effectors of ischemic preconditioning-induced tolerance." @default.
• W2078016508 created "2016-06-24" @default.
• W2078016508 creator A5011426789 @default.
• W2078016508 creator A5021426572 @default.
• W2078016508 creator A5030130178 @default.
• W2078016508 creator A5049904624 @default.
• W2078016508 creator A5053654612 @default.
• W2078016508 creator A5061843273 @default.
• W2078016508 creator A5069808116 @default.
• W2078016508 creator A5089379535 @default.
• W2078016508 date "2009-12-16" @default.
• W2078016508 modified "2023-09-23" @default.
• W2078016508 title "Ischemic Preconditioning Regulates Expression of microRNAs and a Predicted Target, MeCP2, in Mouse Cortex" @default.
• W2078016508 cites W144423133 @default.
• W2078016508 cites W1971234948 @default.
• W2078016508 cites W1984124345 @default.
• W2078016508 cites W1986306041 @default.
• W2078016508 cites W1986710440 @default.
• W2078016508 cites W1988163167 @default.
• W2078016508 cites W1993180746 @default.
• W2078016508 cites W1994210488 @default.
• W2078016508 cites W1994974752 @default.
• W2078016508 cites W2013655994 @default.
• W2078016508 cites W2014946489 @default.
• W2078016508 cites W2017184218 @default.
• W2078016508 cites W2035090622 @default.
• W2078016508 cites W2039276157 @default.
• W2078016508 cites W2040191060 @default.
• W2078016508 cites W2042978306 @default.
• W2078016508 cites W2047124755 @default.
• W2078016508 cites W2059966909 @default.
• W2078016508 cites W2065023418 @default.
• W2078016508 cites W2065566217 @default.
• W2078016508 cites W2073041291 @default.
• W2078016508 cites W2082121151 @default.
• W2078016508 cites W2087962734 @default.
• W2078016508 cites W2089001345 @default.
• W2078016508 cites W2099816146 @default.
• W2078016508 cites W2100325414 @default.
• W2078016508 cites W2103839002 @default.
• W2078016508 cites W2109136664 @default.
• W2078016508 cites W2112505121 @default.
• W2078016508 cites W2120568877 @default.
• W2078016508 cites W2122644537 @default.
• W2078016508 cites W2125622673 @default.
• W2078016508 cites W2127311839 @default.
• W2078016508 cites W2134530067 @default.
• W2078016508 cites W2138473891 @default.
• W2078016508 cites W2138879406 @default.
• W2078016508 cites W2141856214 @default.
• W2078016508 cites W2152041515 @default.
• W2078016508 cites W2153195998 @default.
• W2078016508 cites W2166660871 @default.
• W2078016508 doi "https://doi.org/10.1038/jcbfm.2009.253" @default.
• W2078016508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2935903" @default.
• W2078016508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20010955" @default.
• W2078016508 hasPublicationYear "2009" @default.
• W2078016508 type Work @default.
• W2078016508 sameAs 2078016508 @default.
• W2078016508 citedByCount "148" @default.
• W2078016508 countsByYear W20780165082012 @default.
• W2078016508 countsByYear W20780165082013 @default.
• W2078016508 countsByYear W20780165082014 @default.
• W2078016508 countsByYear W20780165082015 @default.
• W2078016508 countsByYear W20780165082016 @default.
• W2078016508 countsByYear W20780165082017 @default.
• W2078016508 countsByYear W20780165082018 @default.
• W2078016508 countsByYear W20780165082019 @default.
• W2078016508 countsByYear W20780165082020 @default.
• W2078016508 countsByYear W20780165082021 @default.
• W2078016508 countsByYear W20780165082022 @default.
• W2078016508 crossrefType "journal-article" @default.
• W2078016508 hasAuthorship W2078016508A5011426789 @default.
• W2078016508 hasAuthorship W2078016508A5021426572 @default.
• W2078016508 hasAuthorship W2078016508A5030130178 @default.
• W2078016508 hasAuthorship W2078016508A5049904624 @default.
• W2078016508 hasAuthorship W2078016508A5053654612 @default.
• W2078016508 hasAuthorship W2078016508A5061843273 @default.
• W2078016508 hasAuthorship W2078016508A5069808116 @default.
• W2078016508 hasAuthorship W2078016508A5089379535 @default.
• W2078016508 hasBestOaLocation W20780165081 @default.
• W2078016508 hasConcept C104317684 @default.
• W2078016508 hasConcept C105580179 @default.
• W2078016508 hasConcept C126322002 @default.
• W2078016508 hasConcept C127561419 @default.
• W2078016508 hasConcept C127716648 @default.
• W2078016508 hasConcept C145059251 @default.
• W2078016508 hasConcept C149364088 @default.
• W2078016508 hasConcept C165864922 @default.
• W2078016508 hasConcept C169760540 @default.
• W2078016508 hasConcept C25498285 @default.
• W2078016508 hasConcept C2778863441 @default.
• W2078016508 hasConcept C2779311647 @default.
• W2078016508 hasConcept C541997718 @default.
• W2078016508 hasConcept C54355233 @default.
• W2078016508 hasConcept C71924100 @default.
• W2078016508 hasConcept C86803240 @default.
• W2078016508 hasConcept C95444343 @default.

• next