FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078017516> ?p ?o ?g. }

• W2078017516 endingPage "050" @default.
• W2078017516 startingPage "041" @default.
• W2078017516 abstract "Positive hemodynamic effects of the antidiabetic agent rosiglitazone on perfused whole hearts have recently been described, but the mechanisms regulating these effects are not well understood. This study reports the effects of rosiglitazone on calcium regulation in isolated neonatal rat ventricular myocytes by measurement of Ca2+ transient decay rates and SERCA2 gene expression, and shows that rosiglitazone enhances known cardioprotective signaling pathways. Myocyte treatment with 10 micromol/L rosiglitazone accelerated Ca2+ transient decay rates by approximately 30%, enhanced SERCA2 mRNA levels by approximately 1.5-fold and SERCA2 production by approximately 3-fold. Rosiglitazone treatment (1, 5, and 10 micromol/L) also led to a dose-dependent increase (approximately 1.2-1.5-fold) in SERCA2 promoter activity. Comparable levels of cardiac SERCA overexpression have been associated with physiologically relevant and compensatory effects in vivo. These data link thiazolidinedione-induced improvement in cardiac myocyte function to an upregulation of SERCA2 gene expression. Since NF-kappaB-dependent pathways, including the upregulation of IL-6 secretion, were shown to protect neonatal rat ventricular myocytes from apoptosis upon TNFalpha stimulation, additional experiments were designed to determine whether rosiglitazone enhances TNFalpha-induced NF-kappaB-dependent transcription and IL-6 secretion. Because the endotoxin stress response in ventricular myocytes involves the upregulation of TNFalpha, and the activation of NF-kappaB, the effects of rosiglitazone on lipopolysaccharide-induced NF-kappaB-dependent transcription were also investigated. Treatment of neonatal rat ventricular myocytes with 10 micromol/L rosiglitazone enhanced TNF-alpha- and lipopolysaccharide-induced NF-kappaB-dependent transcription by approximately 1.8- and approximately 1.4-fold respectively, and TNF-alpha-induced IL-6 secretion by n1.5-fold. Rosiglitazone had no significant effects on basal levels of NF-kappaB-dependent transcription and IL-6 secretion. Thus, cardioprotective effects of rosiglitazone may be partly mediated by NF-kappaB." @default.
• W2078017516 created "2016-06-24" @default.
• W2078017516 creator A5005487424 @default.
• W2078017516 creator A5010118981 @default.
• W2078017516 creator A5021885248 @default.
• W2078017516 creator A5022794382 @default.
• W2078017516 creator A5025427813 @default.
• W2078017516 creator A5031212448 @default.
• W2078017516 creator A5035464894 @default.
• W2078017516 creator A5036559008 @default.
• W2078017516 creator A5082493706 @default.
• W2078017516 creator A5086877196 @default.
• W2078017516 date "2005-01-01" @default.
• W2078017516 modified "2023-10-17" @default.
• W2078017516 title "The Antidiabetic Agent Rosiglitazone Upregulates SERCA2 and Enhances TNF-α- and LPS-Induced NF-κB-Dependent Transcription and TNF-α-Induced IL-6 Secretion in Ventricular Myocytes" @default.
• W2078017516 cites W1492606093 @default.
• W2078017516 cites W1538880248 @default.
• W2078017516 cites W178764317 @default.
• W2078017516 cites W1964556266 @default.
• W2078017516 cites W1967501975 @default.
• W2078017516 cites W1971036847 @default.
• W2078017516 cites W1976735011 @default.
• W2078017516 cites W1986492139 @default.
• W2078017516 cites W2006918309 @default.
• W2078017516 cites W2016302829 @default.
• W2078017516 cites W2022620673 @default.
• W2078017516 cites W2031206045 @default.
• W2078017516 cites W2034696194 @default.
• W2078017516 cites W2036064400 @default.
• W2078017516 cites W2045303501 @default.
• W2078017516 cites W2053995472 @default.
• W2078017516 cites W2056214235 @default.
• W2078017516 cites W2067275294 @default.
• W2078017516 cites W2086287235 @default.
• W2078017516 cites W2086309499 @default.
• W2078017516 cites W2087150148 @default.
• W2078017516 cites W2102772338 @default.
• W2078017516 cites W2102801331 @default.
• W2078017516 cites W2105719905 @default.
• W2078017516 cites W2106467650 @default.
• W2078017516 cites W2107326660 @default.
• W2078017516 cites W2116329239 @default.
• W2078017516 cites W2140596162 @default.
• W2078017516 cites W2142471538 @default.
• W2078017516 cites W2150033965 @default.
• W2078017516 cites W2157008873 @default.
• W2078017516 cites W2160013321 @default.
• W2078017516 cites W2165870160 @default.
• W2078017516 cites W2429619359 @default.
• W2078017516 cites W4245119819 @default.
• W2078017516 cites W4252969106 @default.
• W2078017516 doi "https://doi.org/10.1159/000083637" @default.
• W2078017516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15665514" @default.
• W2078017516 hasPublicationYear "2005" @default.
• W2078017516 type Work @default.
• W2078017516 sameAs 2078017516 @default.
• W2078017516 citedByCount "27" @default.
• W2078017516 countsByYear W20780175162012 @default.
• W2078017516 countsByYear W20780175162013 @default.
• W2078017516 countsByYear W20780175162014 @default.
• W2078017516 countsByYear W20780175162015 @default.
• W2078017516 countsByYear W20780175162016 @default.
• W2078017516 countsByYear W20780175162018 @default.
• W2078017516 countsByYear W20780175162019 @default.
• W2078017516 countsByYear W20780175162020 @default.
• W2078017516 countsByYear W20780175162021 @default.
• W2078017516 countsByYear W20780175162023 @default.
• W2078017516 crossrefType "journal-article" @default.
• W2078017516 hasAuthorship W2078017516A5005487424 @default.
• W2078017516 hasAuthorship W2078017516A5010118981 @default.
• W2078017516 hasAuthorship W2078017516A5021885248 @default.
• W2078017516 hasAuthorship W2078017516A5022794382 @default.
• W2078017516 hasAuthorship W2078017516A5025427813 @default.
• W2078017516 hasAuthorship W2078017516A5031212448 @default.
• W2078017516 hasAuthorship W2078017516A5035464894 @default.
• W2078017516 hasAuthorship W2078017516A5036559008 @default.
• W2078017516 hasAuthorship W2078017516A5082493706 @default.
• W2078017516 hasAuthorship W2078017516A5086877196 @default.
• W2078017516 hasBestOaLocation W20780175161 @default.
• W2078017516 hasConcept C104317684 @default.
• W2078017516 hasConcept C126322002 @default.
• W2078017516 hasConcept C127561419 @default.
• W2078017516 hasConcept C134018914 @default.
• W2078017516 hasConcept C170493617 @default.
• W2078017516 hasConcept C17991360 @default.
• W2078017516 hasConcept C185592680 @default.
• W2078017516 hasConcept C207200792 @default.
• W2078017516 hasConcept C2780152017 @default.
• W2078017516 hasConcept C55493867 @default.
• W2078017516 hasConcept C71924100 @default.
• W2078017516 hasConcept C86803240 @default.
• W2078017516 hasConceptScore W2078017516C104317684 @default.
• W2078017516 hasConceptScore W2078017516C126322002 @default.
• W2078017516 hasConceptScore W2078017516C127561419 @default.
• W2078017516 hasConceptScore W2078017516C134018914 @default.
• W2078017516 hasConceptScore W2078017516C170493617 @default.
• W2078017516 hasConceptScore W2078017516C17991360 @default.
• W2078017516 hasConceptScore W2078017516C185592680 @default.

• next