FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078017764> ?p ?o ?g. }

• W2078017764 endingPage "242" @default.
• W2078017764 startingPage "227" @default.
• W2078017764 abstract "2-Butoxyethanol (2BE) is used extensively in the production of cleaning agents and solvents. It is primarily metabolized in the liver to 2-butoxyacetic acid (2BAA), which is believed to be responsible for 2BE toxicities associated with hemolysis of red blood cells. The objective of the study was to characterize the systemic disposition of 2BE and 2BAA in rats and mice during 2-year 2BE inhalation toxicity studies. Male and female F344 rats and B6C3F1 mice (6–7 weeks old) were exposed to target 2BE concentrations of 0, 31.2, 62.5, or 125 ppm (rats), or 0, 62.5, 125, or 250 ppm (mice), by whole-body inhalation for 6 h/day, 5 days/week for up to 18 months. Postexposure blood samples were collected after 1 day, 2 weeks, and 3, 6, 12, and 18 months of exposure. Postexposure 16-h urine samples were collected after 2 weeks and 3, 6, 12, and 18 months of exposure. A separate set of mice was kept in the control chamber and exposed to 2BE for 3 weeks when they were approximately 19 months old. Postexposure blood samples were collected after 1 day and 3 weeks of exposure and 16-h urine samples were collected after 2 weeks of exposure from these aged mice. Blood samples were analyzed for both 2BE and 2BAA and urine samples were analyzed for 2BAA using GC/MS, and their kinetic parameters were estimated through the curve-fitting method using SAS. Systemically absorbed 2BE was rapidly cleared from blood (t1/2-RAT< 10 min;t1/2-MOUSE< 5 min after the 1-day exposure) independent of exposure concentration. Proportional increases in AUC2BErelative to increases in exposure concentration indicated linear 2BE kinetics. In contrast, the rate of 2BAA elimination from blood decreased as the exposure concentration increased. Nonproportional increases in AUC2BAAalso indicated that 2BAA is eliminated following dose-dependent, nonlinear kinetics. Overall, mice eliminated both 2BE and 2BAA from blood faster than rats. Sex-related differences in 2BAA elimination were most significant with rats, in that females were less efficient in clearing 2BAA from the blood. Differences in renal excretion of 2BAA are possibly responsible for the sex-related difference in the 2BAA blood profiles in rats. As exposure continued, the rates of elimination for both 2BE and 2BAA decreased in both species, resulting in longer residence times in the blood. When 19-month-old naive mice were exposed to 125 ppm, 2BE was rapidly cleared from the systemic circulation, exhibiting clearance profiles similar to young mice. However, old mice eliminated 2BAA from blood > 10 times slower than young mice after 1-day of exposure. This delayed elimination of 2BAA in old mice was less obvious after 3 weeks of exposure, suggesting that there might be other factors in addition to the age of animals that could influence the apparent difference in 2BAA kinetics between old and young mice. It was concluded that the elimination kinetics of 2BE and 2BAA following repeated 2BE exposure appear to be dependent on species, sex, age, time of exposure, as well as the exposure concentration." @default.
• W2078017764 created "2016-06-24" @default.
• W2078017764 creator A5004685671 @default.
• W2078017764 creator A5008132820 @default.
• W2078017764 creator A5023979316 @default.
• W2078017764 creator A5025757475 @default.
• W2078017764 creator A5037859265 @default.
• W2078017764 creator A5073439001 @default.
• W2078017764 creator A5073992167 @default.
• W2078017764 creator A5085260043 @default.
• W2078017764 date "1998-12-01" @default.
• W2078017764 modified "2023-10-09" @default.
• W2078017764 title "Toxicokinetics of Inhaled 2-Butoxyethanol and Its Major Metabolite, 2-Butoxyacetic Acid, in F344 Rats and B6C3F1 Mice" @default.
• W2078017764 cites W1641536023 @default.
• W2078017764 cites W1976340061 @default.
• W2078017764 cites W1979844633 @default.
• W2078017764 cites W1988774850 @default.
• W2078017764 cites W1989408625 @default.
• W2078017764 cites W2002113392 @default.
• W2078017764 cites W2003384540 @default.
• W2078017764 cites W2016136432 @default.
• W2078017764 cites W2027306803 @default.
• W2078017764 cites W2028054748 @default.
• W2078017764 cites W2052123662 @default.
• W2078017764 cites W2054389794 @default.
• W2078017764 cites W2055024090 @default.
• W2078017764 cites W2057207156 @default.
• W2078017764 cites W2057940784 @default.
• W2078017764 cites W2077693388 @default.
• W2078017764 cites W2082313554 @default.
• W2078017764 cites W2087110397 @default.
• W2078017764 cites W2089237834 @default.
• W2078017764 cites W2134640560 @default.
• W2078017764 cites W2156661627 @default.
• W2078017764 cites W2916661696 @default.
• W2078017764 doi "https://doi.org/10.1006/taap.1998.8524" @default.
• W2078017764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9878593" @default.
• W2078017764 hasPublicationYear "1998" @default.
• W2078017764 type Work @default.
• W2078017764 sameAs 2078017764 @default.
• W2078017764 citedByCount "22" @default.
• W2078017764 countsByYear W20780177642012 @default.
• W2078017764 countsByYear W20780177642016 @default.
• W2078017764 crossrefType "journal-article" @default.
• W2078017764 hasAuthorship W2078017764A5004685671 @default.
• W2078017764 hasAuthorship W2078017764A5008132820 @default.
• W2078017764 hasAuthorship W2078017764A5023979316 @default.
• W2078017764 hasAuthorship W2078017764A5025757475 @default.
• W2078017764 hasAuthorship W2078017764A5037859265 @default.
• W2078017764 hasAuthorship W2078017764A5073439001 @default.
• W2078017764 hasAuthorship W2078017764A5073992167 @default.
• W2078017764 hasAuthorship W2078017764A5085260043 @default.
• W2078017764 hasConcept C112705442 @default.
• W2078017764 hasConcept C126322002 @default.
• W2078017764 hasConcept C185592680 @default.
• W2078017764 hasConcept C195289149 @default.
• W2078017764 hasConcept C2776820430 @default.
• W2078017764 hasConcept C2776954882 @default.
• W2078017764 hasConcept C2777477808 @default.
• W2078017764 hasConcept C2779777708 @default.
• W2078017764 hasConcept C2779902561 @default.
• W2078017764 hasConcept C2780026642 @default.
• W2078017764 hasConcept C29730261 @default.
• W2078017764 hasConcept C33070731 @default.
• W2078017764 hasConcept C42219234 @default.
• W2078017764 hasConcept C42407357 @default.
• W2078017764 hasConcept C55493867 @default.
• W2078017764 hasConcept C71924100 @default.
• W2078017764 hasConcept C86803240 @default.
• W2078017764 hasConcept C98274493 @default.
• W2078017764 hasConceptScore W2078017764C112705442 @default.
• W2078017764 hasConceptScore W2078017764C126322002 @default.
• W2078017764 hasConceptScore W2078017764C185592680 @default.
• W2078017764 hasConceptScore W2078017764C195289149 @default.
• W2078017764 hasConceptScore W2078017764C2776820430 @default.
• W2078017764 hasConceptScore W2078017764C2776954882 @default.
• W2078017764 hasConceptScore W2078017764C2777477808 @default.
• W2078017764 hasConceptScore W2078017764C2779777708 @default.
• W2078017764 hasConceptScore W2078017764C2779902561 @default.
• W2078017764 hasConceptScore W2078017764C2780026642 @default.
• W2078017764 hasConceptScore W2078017764C29730261 @default.
• W2078017764 hasConceptScore W2078017764C33070731 @default.
• W2078017764 hasConceptScore W2078017764C42219234 @default.
• W2078017764 hasConceptScore W2078017764C42407357 @default.
• W2078017764 hasConceptScore W2078017764C55493867 @default.
• W2078017764 hasConceptScore W2078017764C71924100 @default.
• W2078017764 hasConceptScore W2078017764C86803240 @default.
• W2078017764 hasConceptScore W2078017764C98274493 @default.
• W2078017764 hasIssue "2" @default.
• W2078017764 hasLocation W20780177641 @default.
• W2078017764 hasLocation W20780177642 @default.
• W2078017764 hasOpenAccess W2078017764 @default.
• W2078017764 hasPrimaryLocation W20780177641 @default.
• W2078017764 hasRelatedWork W1613434511 @default.
• W2078017764 hasRelatedWork W1977173016 @default.
• W2078017764 hasRelatedWork W1990518082 @default.
• W2078017764 hasRelatedWork W1998870511 @default.
• W2078017764 hasRelatedWork W2026304952 @default.

• next