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• W2078017835 startingPage "1612" @default.
• W2078017835 abstract "Increasing prevalence of inflammatory bowel disease may be due to imbalance in the intake of n -6 and n -3 PUFA in the diet. This study investigates the impact of varying ratios of dietary linoleic acid (LA, 18 : 2 n -6) to α-linolenic acid (ALA, 18 : 3 n -3) on the inflammatory response in dextran sulphate sodium (DSS)-induced colitis. Weanling male Sprague–Dawley rats were divided into five groups: a non-colitic group with a LA:ALA ratio of 215 (CON-215), and colitic groups with LA:ALA ratios of 215 (DSS-215), 50 (DSS-50), 10 (DSS-10) and 2 (DSS-2). Blends of groundnut, palmolein and linseed oils were used to provide varying LA:ALA ratios. All the rats were fed the respective experimental isoenergetic diets containing 10 % fat for 90 d and DSS was administered during the last 11 d. Colonic inflammation was evaluated by clinical, biochemical and histological parameters. The results showed attenuation of colitis in the DSS-2 group as evidenced by significant reductions in disease activity index, mucosal myeloperoxidase activity ( P < 0·05), alkaline phosphatase activity ( P < 0·01) and increase in colon length ( P < 0·01) compared to the groups fed with higher ratios (DSS-215). This was accompanied by significant reductions in mucosal proinflammatory cytokines TNF-α ( P < 0·01) and IL-1β ( P < 0·01) and improvement in the histological score. Further, ALA supplementation increased long-chain (LC) n -3 PUFA and decreased LC n -6 PUFA in colon structural lipids. These data suggest that substitution of one-third of LA with ALA (LA:ALA ratio 2) mitigates experimental colitis by down-regulating proinflammatory mediators." @default.
• W2078017835 created "2016-06-24" @default.
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• W2078017835 date "2012-01-16" @default.
• W2078017835 modified "2023-10-14" @default.
• W2078017835 title "Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease" @default.
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• W2078017835 doi "https://doi.org/10.1017/s0007114511007197" @default.
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