FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078018449> ?p ?o ?g. }

• W2078018449 endingPage "8053" @default.
• W2078018449 startingPage "8044" @default.
• W2078018449 abstract "Leishmaniasis and Chagas' disease constitute a relevant health and socio-economic problem in Latin America, Africa, and Asia. The therapeutic interventions rely on inefficient and highly toxic drugs with systemic side effects in patients. Considering the multiple biological activities of the calcium channel blockers and the high versatility of 1,4-dihydropyridines, eight clinically used 1,4-dihydropyridines (azelnidipine, amlodipine, cilnidipine, lercanidipine, nicardipine, nifedipine, nimodipine and nitrendipine) were in vitro tested against Leishmania and Trypanosoma cruzi parasites, and their cytotoxicity was tested against mammalian cells. In addition, a QSAR study was performed in order to delineate further structural requirements for the anti-protozoan activity and to predict the biological potency of 1,4-dihydropyridines. The tested compounds were effective against Leishmania (L.) amazonensis, Leishmania (V.)braziliensis, Leishmania (L.) chagasi, and Leishmania (L.) major promastigotes, L. (L.) chagasi intracellular amastigotes and T. cruzi trypomastigotes with 50% inhibitory concentration (IC(50)) values in the range of 2.6-181μM. The QSAR provided useful information about the structural features of the anti-protozoan activities, including diphenylpropyl and diphenylmethylazetidin groups at position 4 of the 1,4-dihydropyridine ring, allowing the prediction of two novel potential anti-protozoan analogs." @default.
• W2078018449 created "2016-06-24" @default.
• W2078018449 creator A5008833161 @default.
• W2078018449 creator A5012850312 @default.
• W2078018449 creator A5044913303 @default.
• W2078018449 date "2010-11-15" @default.
• W2078018449 modified "2023-10-16" @default.
• W2078018449 title "Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure–activity relationship study" @default.
• W2078018449 cites W1519177607 @default.
• W2078018449 cites W1545231783 @default.
• W2078018449 cites W1964114566 @default.
• W2078018449 cites W1970777540 @default.
• W2078018449 cites W1973623037 @default.
• W2078018449 cites W1984979458 @default.
• W2078018449 cites W1991619291 @default.
• W2078018449 cites W1993180192 @default.
• W2078018449 cites W1995379006 @default.
• W2078018449 cites W1995532271 @default.
• W2078018449 cites W2004076168 @default.
• W2078018449 cites W2013407109 @default.
• W2078018449 cites W2019623323 @default.
• W2078018449 cites W2023611106 @default.
• W2078018449 cites W2024589291 @default.
• W2078018449 cites W2037328302 @default.
• W2078018449 cites W2056386522 @default.
• W2078018449 cites W2059390591 @default.
• W2078018449 cites W2064312352 @default.
• W2078018449 cites W2073319896 @default.
• W2078018449 cites W2084222138 @default.
• W2078018449 cites W2084340137 @default.
• W2078018449 cites W2113189708 @default.
• W2078018449 cites W2128658547 @default.
• W2078018449 cites W2132487256 @default.
• W2078018449 cites W2152545048 @default.
• W2078018449 cites W2241011319 @default.
• W2078018449 cites W2324185390 @default.
• W2078018449 cites W2736805338 @default.
• W2078018449 cites W2766040292 @default.
• W2078018449 cites W2949801754 @default.
• W2078018449 doi "https://doi.org/10.1016/j.bmc.2010.09.015" @default.
• W2078018449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20934347" @default.
• W2078018449 hasPublicationYear "2010" @default.
• W2078018449 type Work @default.
• W2078018449 sameAs 2078018449 @default.
• W2078018449 citedByCount "51" @default.
• W2078018449 countsByYear W20780184492012 @default.
• W2078018449 countsByYear W20780184492013 @default.
• W2078018449 countsByYear W20780184492014 @default.
• W2078018449 countsByYear W20780184492015 @default.
• W2078018449 countsByYear W20780184492016 @default.
• W2078018449 countsByYear W20780184492017 @default.
• W2078018449 countsByYear W20780184492018 @default.
• W2078018449 countsByYear W20780184492019 @default.
• W2078018449 countsByYear W20780184492020 @default.
• W2078018449 countsByYear W20780184492021 @default.
• W2078018449 countsByYear W20780184492022 @default.
• W2078018449 countsByYear W20780184492023 @default.
• W2078018449 crossrefType "journal-article" @default.
• W2078018449 hasAuthorship W2078018449A5008833161 @default.
• W2078018449 hasAuthorship W2078018449A5012850312 @default.
• W2078018449 hasAuthorship W2078018449A5044913303 @default.
• W2078018449 hasConcept C136764020 @default.
• W2078018449 hasConcept C178790620 @default.
• W2078018449 hasConcept C185592680 @default.
• W2078018449 hasConcept C203014093 @default.
• W2078018449 hasConcept C2776555147 @default.
• W2078018449 hasConcept C2777625466 @default.
• W2078018449 hasConcept C2778689377 @default.
• W2078018449 hasConcept C2779066535 @default.
• W2078018449 hasConcept C2779121891 @default.
• W2078018449 hasConcept C2781092759 @default.
• W2078018449 hasConcept C2909011054 @default.
• W2078018449 hasConcept C41008148 @default.
• W2078018449 hasConcept C519063684 @default.
• W2078018449 hasConcept C55493867 @default.
• W2078018449 hasConcept C71928629 @default.
• W2078018449 hasConcept C86803240 @default.
• W2078018449 hasConcept C98274493 @default.
• W2078018449 hasConcept C98319499 @default.
• W2078018449 hasConceptScore W2078018449C136764020 @default.
• W2078018449 hasConceptScore W2078018449C178790620 @default.
• W2078018449 hasConceptScore W2078018449C185592680 @default.
• W2078018449 hasConceptScore W2078018449C203014093 @default.
• W2078018449 hasConceptScore W2078018449C2776555147 @default.
• W2078018449 hasConceptScore W2078018449C2777625466 @default.
• W2078018449 hasConceptScore W2078018449C2778689377 @default.
• W2078018449 hasConceptScore W2078018449C2779066535 @default.
• W2078018449 hasConceptScore W2078018449C2779121891 @default.
• W2078018449 hasConceptScore W2078018449C2781092759 @default.
• W2078018449 hasConceptScore W2078018449C2909011054 @default.
• W2078018449 hasConceptScore W2078018449C41008148 @default.
• W2078018449 hasConceptScore W2078018449C519063684 @default.
• W2078018449 hasConceptScore W2078018449C55493867 @default.
• W2078018449 hasConceptScore W2078018449C71928629 @default.
• W2078018449 hasConceptScore W2078018449C86803240 @default.
• W2078018449 hasConceptScore W2078018449C98274493 @default.
• W2078018449 hasConceptScore W2078018449C98319499 @default.
• W2078018449 hasIssue "22" @default.

• next