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- W2078019594 abstract "The role of the Fcϵ, receptor (FcϵR), isolated from rat basophilic leukemia cells (line RBL-2H3) in antigen induced Ca++ channel opening has been studied by following ion conductance in reconstituted model membranes. Planar bilayers were constructed from lipid vesicles containing the purified FcϵR alone, or together with the cromolyn binding protein (CBP). Changes in conductivity of these bilayers were measured as a monitor for channel activity, following specific aggregation of FcϵR. Antigen-induced, FcϵR mediated channel activity could only be elicited in membranes containing both proteins. This conductance was abrogated upon disaggregating the complexes with a monovalent hapten (ϵ-N-DNP-l-lysine). No channel activity was observed following antigen-induced aggregation of FcϵR if CBP was not present in the bilayer. The single channels recorded were of ≈2 pS conductance. The open-time values varied significantly with individual experiments and depended on the protein composition of the membrane and the nature of the aggregating agent. These observations strongly indicate that the FcϵR isolated from RBL cells does not form cation (Ca++) channels by itself. Furthermore, in line with earlier reports, the present data suggest that the CBP is responsible for this activity, and that it interacts directly with FcϵR to open channels upon aggregation." @default.
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- W2078019594 date "1986-01-01" @default.
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- W2078019594 title "The role of the Fcϵ receptor in calcium channel opening in rat basophilic leukemia cells" @default.
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- W2078019594 doi "https://doi.org/10.1016/0165-2478(86)90077-5" @default.
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