FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078030908> ?p ?o ?g. }

• W2078030908 endingPage "1812" @default.
• W2078030908 startingPage "1806" @default.
• W2078030908 abstract "The study evaluates the effects of genistein on blood pressure (BP) and ultrastructural changes in kidney of fructose-fed hypertensive rats. Male Wistar rats were fed a diet containing 60 % starch or 60 % fructose as the source of carbohydrate. After 15 d, rats in each dietary group were divided into two groups and were treated with either genistein (1 mg/kg per d) in dimethylsulfoxide (DMSO) or 30 % DMSO alone. BP, pressor mechanisms, protein kinase C-βII (PKC-βII) expression, endothelial NO synthase (eNOS) expression and renal ultrastructural changes were evaluated after 60 d. Fructose-fed rats displayed significant elevation in BP and heart rate. Significant increase in plasma angiotensin-converting enzyme (ACE) activity, alterations in renal lipid profile, nitrite and kallikrein activity, enhanced expression of membrane-associated PKC-βII and decreased expression of eNOS were observed in them. Histology and electron microscopic studies showed structural changes in the kidney. Genistein administration lowered BP, restored ACE, PKC-βII and eNOS expression and preserved renal ultrastructural integrity. These findings demonstrate that genistein has effects on eNOS activity in renal cells, leading to eNOS activation and NO synthesis. These effects could have been mediated by activation of PKC-βII. The observed benefits of genistein make it a promising candidate for therapy of diabetic kidney disease." @default.
• W2078030908 created "2016-06-24" @default.
• W2078030908 creator A5026572121 @default.
• W2078030908 creator A5054714549 @default.
• W2078030908 date "2012-09-21" @default.
• W2078030908 modified "2023-10-11" @default.
• W2078030908 title "Beneficial effect of genistein on lowering blood pressure and kidney toxicity in fructose-fed hypertensive rats" @default.
• W2078030908 cites W1603740748 @default.
• W2078030908 cites W1775749144 @default.
• W2078030908 cites W1965227795 @default.
• W2078030908 cites W1967172766 @default.
• W2078030908 cites W1972859660 @default.
• W2078030908 cites W1978979590 @default.
• W2078030908 cites W1999260487 @default.
• W2078030908 cites W2000587250 @default.
• W2078030908 cites W2001385601 @default.
• W2078030908 cites W2010844748 @default.
• W2078030908 cites W2013684570 @default.
• W2078030908 cites W2019498941 @default.
• W2078030908 cites W2055608881 @default.
• W2078030908 cites W2060868399 @default.
• W2078030908 cites W2061498158 @default.
• W2078030908 cites W2062282696 @default.
• W2078030908 cites W2079221797 @default.
• W2078030908 cites W2086374646 @default.
• W2078030908 cites W2087707800 @default.
• W2078030908 cites W2091508965 @default.
• W2078030908 cites W2094555512 @default.
• W2078030908 cites W2114289687 @default.
• W2078030908 cites W2115923843 @default.
• W2078030908 cites W2126635187 @default.
• W2078030908 cites W2135671873 @default.
• W2078030908 cites W2148526752 @default.
• W2078030908 cites W2157406373 @default.
• W2078030908 cites W2160159832 @default.
• W2078030908 cites W2161007481 @default.
• W2078030908 cites W2169768470 @default.
• W2078030908 doi "https://doi.org/10.1017/s0007114512003819" @default.
• W2078030908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23116847" @default.
• W2078030908 hasPublicationYear "2012" @default.
• W2078030908 type Work @default.
• W2078030908 sameAs 2078030908 @default.
• W2078030908 citedByCount "43" @default.
• W2078030908 countsByYear W20780309082012 @default.
• W2078030908 countsByYear W20780309082013 @default.
• W2078030908 countsByYear W20780309082014 @default.
• W2078030908 countsByYear W20780309082015 @default.
• W2078030908 countsByYear W20780309082016 @default.
• W2078030908 countsByYear W20780309082017 @default.
• W2078030908 countsByYear W20780309082018 @default.
• W2078030908 countsByYear W20780309082019 @default.
• W2078030908 countsByYear W20780309082020 @default.
• W2078030908 countsByYear W20780309082021 @default.
• W2078030908 countsByYear W20780309082022 @default.
• W2078030908 countsByYear W20780309082023 @default.
• W2078030908 crossrefType "journal-article" @default.
• W2078030908 hasAuthorship W2078030908A5026572121 @default.
• W2078030908 hasAuthorship W2078030908A5054714549 @default.
• W2078030908 hasBestOaLocation W20780309081 @default.
• W2078030908 hasConcept C126322002 @default.
• W2078030908 hasConcept C134018914 @default.
• W2078030908 hasConcept C185592680 @default.
• W2078030908 hasConcept C2776970464 @default.
• W2078030908 hasConcept C2777622882 @default.
• W2078030908 hasConcept C2778298627 @default.
• W2078030908 hasConcept C2778326061 @default.
• W2078030908 hasConcept C2780091579 @default.
• W2078030908 hasConcept C519581460 @default.
• W2078030908 hasConcept C55493867 @default.
• W2078030908 hasConcept C71924100 @default.
• W2078030908 hasConcept C84393581 @default.
• W2078030908 hasConcept C86803240 @default.
• W2078030908 hasConceptScore W2078030908C126322002 @default.
• W2078030908 hasConceptScore W2078030908C134018914 @default.
• W2078030908 hasConceptScore W2078030908C185592680 @default.
• W2078030908 hasConceptScore W2078030908C2776970464 @default.
• W2078030908 hasConceptScore W2078030908C2777622882 @default.
• W2078030908 hasConceptScore W2078030908C2778298627 @default.
• W2078030908 hasConceptScore W2078030908C2778326061 @default.
• W2078030908 hasConceptScore W2078030908C2780091579 @default.
• W2078030908 hasConceptScore W2078030908C519581460 @default.
• W2078030908 hasConceptScore W2078030908C55493867 @default.
• W2078030908 hasConceptScore W2078030908C71924100 @default.
• W2078030908 hasConceptScore W2078030908C84393581 @default.
• W2078030908 hasConceptScore W2078030908C86803240 @default.
• W2078030908 hasIssue "10" @default.
• W2078030908 hasLocation W20780309081 @default.
• W2078030908 hasLocation W20780309082 @default.
• W2078030908 hasOpenAccess W2078030908 @default.
• W2078030908 hasPrimaryLocation W20780309081 @default.
• W2078030908 hasRelatedWork W114349860 @default.
• W2078030908 hasRelatedWork W2002628816 @default.
• W2078030908 hasRelatedWork W2045596249 @default.
• W2078030908 hasRelatedWork W2313377632 @default.
• W2078030908 hasRelatedWork W2327357785 @default.
• W2078030908 hasRelatedWork W2354184574 @default.
• W2078030908 hasRelatedWork W2379655167 @default.
• W2078030908 hasRelatedWork W2392497817 @default.

• next