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• W2078045155 endingPage "e21232" @default.
• W2078045155 startingPage "e21232" @default.
• W2078045155 abstract "Background Several studies have correlated perinatal malnutrition with diseases in adulthood, giving support to the programming hypothesis. In this study, the effects of maternal undernutrition during lactation on renal Na+-transporters and on the local angiotensin II (Ang II) signaling cascade in rats were investigated. Methodology/Principal Findings Female rats received a hypoproteic diet (8% protein) throughout lactation. Control and programmed offspring consumed a diet containing 20% protein after weaning. Programming caused a decrease in the number of nephrons (35%), in the area of the Bowman's capsule (30%) and the capillary tuft (30%), and increased collagen deposition in the cortex and medulla (by 175% and 700%, respectively). In programmed rats the expression of (Na++K+)ATPase in proximal tubules increased by 40%, but its activity was doubled owing to a threefold increase in affinity for K+. Programming doubled the ouabain-insensitive Na+-ATPase activity with loss of its physiological response to Ang II, increased the expression of AT1 and decreased the expression of AT2 receptors), and caused a pronounced inhibition (90%) of protein kinase C activity with decrease in the expression of the α (24%) and ε (13%) isoforms. Activity and expression of cyclic AMP-dependent protein kinase decreased in the same proportion as the AT2 receptors (30%). In vivo studies at 60 days revealed an increased glomerular filtration rate (GFR) (70%), increased Na+ excretion (80%) and intense proteinuria (increase of 400% in protein excretion). Programmed rats, which had normal arterial pressure at 60 days, became hypertensive by 150 days. Conclusions/Significance Maternal protein restriction during lactation results in alterations in GFR, renal Na+ handling and in components of the Ang II-linked regulatory pathway of renal Na+ reabsorption. At the molecular level, they provide a framework for understanding how metabolic programming of renal mechanisms contributes to the onset of hypertension in adulthood." @default.
• W2078045155 created "2016-06-24" @default.
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• W2078045155 date "2011-07-01" @default.
• W2078045155 modified "2023-09-26" @default.
• W2078045155 title "Metabolic Programming during Lactation Stimulates Renal Na+ Transport in the Adult Offspring Due to an Early Impact on Local Angiotensin II Pathways" @default.
• W2078045155 cites W1025309238 @default.
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• W2078045155 cites W1570910952 @default.
• W2078045155 cites W1584492497 @default.
• W2078045155 cites W1589135378 @default.
• W2078045155 cites W1775749144 @default.
• W2078045155 cites W1831301545 @default.
• W2078045155 cites W1854869070 @default.
• W2078045155 cites W189337645 @default.
• W2078045155 cites W1963528868 @default.
• W2078045155 cites W1967679464 @default.
• W2078045155 cites W1968786994 @default.
• W2078045155 cites W1974765210 @default.
• W2078045155 cites W1980543406 @default.
• W2078045155 cites W1985891842 @default.
• W2078045155 cites W1986249790 @default.
• W2078045155 cites W1986990637 @default.
• W2078045155 cites W1987966313 @default.
• W2078045155 cites W1992927110 @default.
• W2078045155 cites W1995948186 @default.
• W2078045155 cites W1997217160 @default.
• W2078045155 cites W2004372218 @default.
• W2078045155 cites W2006190738 @default.
• W2078045155 cites W2009968854 @default.
• W2078045155 cites W2012404289 @default.
• W2078045155 cites W2014921738 @default.
• W2078045155 cites W2031840958 @default.
• W2078045155 cites W2034961623 @default.
• W2078045155 cites W2036867915 @default.
• W2078045155 cites W2038479789 @default.
• W2078045155 cites W2048636267 @default.
• W2078045155 cites W2050184004 @default.
• W2078045155 cites W2051004897 @default.
• W2078045155 cites W2051124291 @default.
• W2078045155 cites W2051836550 @default.
• W2078045155 cites W2052051702 @default.
• W2078045155 cites W2052405408 @default.
• W2078045155 cites W2055445243 @default.
• W2078045155 cites W2058906411 @default.
• W2078045155 cites W2061675956 @default.
• W2078045155 cites W2062336638 @default.
• W2078045155 cites W2064196450 @default.
• W2078045155 cites W2066618332 @default.
• W2078045155 cites W2067234938 @default.
• W2078045155 cites W2069734547 @default.
• W2078045155 cites W2078118683 @default.
• W2078045155 cites W2081544488 @default.
• W2078045155 cites W2103591594 @default.
• W2078045155 cites W2103822775 @default.
• W2078045155 cites W2108968939 @default.
• W2078045155 cites W2110003371 @default.
• W2078045155 cites W2110421924 @default.
• W2078045155 cites W2114614037 @default.
• W2078045155 cites W2116563193 @default.
• W2078045155 cites W2120699999 @default.
• W2078045155 cites W2135266728 @default.
• W2078045155 cites W2162878054 @default.
• W2078045155 cites W2164337114 @default.
• W2078045155 cites W2167712860 @default.
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• W2078045155 doi "https://doi.org/10.1371/journal.pone.0021232" @default.
• W2078045155 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3128598" @default.
• W2078045155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21747933" @default.
• W2078045155 hasPublicationYear "2011" @default.
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