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- W2078046758 abstract "The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively studied in many diverse paradigms using acute stimuli. Recent attention has focussed on long-term elevation of Fos-related antigens in the CNS, and this is discussed by Keith Pennypacker, Jau-S. Hong and Michael McMillian. Repeated or chronic treatment elevates Fos-related antigen levels for days in many different brain regions. Both direct and indirect stimulation are responsible for the protracted increase in Fos-related antigen-immunoreactive proteins, which may modulate late onset genes involved in neuroplasticity. Understanding the role of these factors in long-lasting or permanent disease states may provide insight into potential therapeutic strategies to treat chronic CNS disorders." @default.
- W2078046758 created "2016-06-24" @default.
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- W2078046758 date "1995-09-01" @default.
- W2078046758 modified "2023-10-18" @default.
- W2078046758 title "Implications of prolonged expression of Fos-related antigens" @default.
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- W2078046758 doi "https://doi.org/10.1016/s0165-6147(00)89061-6" @default.
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