FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078047319> ?p ?o ?g. }

• W2078047319 endingPage "18" @default.
• W2078047319 startingPage "11" @default.
• W2078047319 abstract "In a recent work by our group involving a transcriptomics approach applied to the venom glands from Tityus stigmurus we identified a new family of peptides called Hypotensins (TSTI0006C) (Almeida et al., 2012). The cluster TSTI0006C was analyzed in the main 25 amino acid residues and named T. stigmurus Hypotensin (TistH), showing a molecular mass of 2.7 kDa, an absence of cysteines and the presence of two C-terminal proline residues, which are a bradykinin-potentiating peptide (BPP) signature. Here, we describe the homology modeling of the three-dimensional structure of TistH. In addition, we evaluated the cardiovascular effects elicited by TistH in normotensive rats. Firstly, TistH showed no cytotoxic effect on horse erythrocyte. Furthermore, in normotensive rats TistH was able to potentiate the hypotensive action of bradykinin (BK) and induced a vasorelaxant effect in mesenteric artery rings by endothelium-dependent release of nitric oxide (NO) and demonstrated independent inhibition of angiotensin converting enzyme (ACE). Our data can contribute to a better understanding of the structural and functional characteristics of TistH and suggest its potential use in cardiovascular diseases." @default.
• W2078047319 created "2016-06-24" @default.
• W2078047319 creator A5017655268 @default.
• W2078047319 creator A5036663494 @default.
• W2078047319 creator A5044487476 @default.
• W2078047319 creator A5048499185 @default.
• W2078047319 creator A5048661242 @default.
• W2078047319 creator A5056121017 @default.
• W2078047319 creator A5058976153 @default.
• W2078047319 creator A5063872688 @default.
• W2078047319 date "2015-07-01" @default.
• W2078047319 modified "2023-10-17" @default.
• W2078047319 title "Homology modeling, vasorelaxant and bradykinin-potentiating activities of a novel hypotensin found in the scorpion venom from Tityus stigmurus" @default.
• W2078047319 cites W1516459493 @default.
• W2078047319 cites W1964720985 @default.
• W2078047319 cites W1966182689 @default.
• W2078047319 cites W1973899958 @default.
• W2078047319 cites W1974295991 @default.
• W2078047319 cites W1975744071 @default.
• W2078047319 cites W1976499671 @default.
• W2078047319 cites W1980804718 @default.
• W2078047319 cites W1986191025 @default.
• W2078047319 cites W1988636074 @default.
• W2078047319 cites W1993857417 @default.
• W2078047319 cites W1994025057 @default.
• W2078047319 cites W2010211647 @default.
• W2078047319 cites W2012893043 @default.
• W2078047319 cites W2013186307 @default.
• W2078047319 cites W2016614106 @default.
• W2078047319 cites W2028202696 @default.
• W2078047319 cites W2029667189 @default.
• W2078047319 cites W2033906450 @default.
• W2078047319 cites W2034690727 @default.
• W2078047319 cites W2034963012 @default.
• W2078047319 cites W2035266068 @default.
• W2078047319 cites W2037312364 @default.
• W2078047319 cites W2044926508 @default.
• W2078047319 cites W2048866816 @default.
• W2078047319 cites W2049082327 @default.
• W2078047319 cites W2055043387 @default.
• W2078047319 cites W2055404864 @default.
• W2078047319 cites W2060259273 @default.
• W2078047319 cites W2060809301 @default.
• W2078047319 cites W2065283382 @default.
• W2078047319 cites W2067970470 @default.
• W2078047319 cites W2069123478 @default.
• W2078047319 cites W2070197928 @default.
• W2078047319 cites W2073685932 @default.
• W2078047319 cites W2074986801 @default.
• W2078047319 cites W2079118006 @default.
• W2078047319 cites W2080424717 @default.
• W2078047319 cites W2081786688 @default.
• W2078047319 cites W2085466541 @default.
• W2078047319 cites W2086061757 @default.
• W2078047319 cites W2090999898 @default.
• W2078047319 cites W2112216439 @default.
• W2078047319 cites W2120230374 @default.
• W2078047319 cites W2128572087 @default.
• W2078047319 cites W2137015675 @default.
• W2078047319 cites W2141493271 @default.
• W2078047319 cites W2143914955 @default.
• W2078047319 cites W2154714625 @default.
• W2078047319 cites W2156818122 @default.
• W2078047319 cites W2162166182 @default.
• W2078047319 cites W2171268876 @default.
• W2078047319 cites W4245437819 @default.
• W2078047319 doi "https://doi.org/10.1016/j.toxicon.2015.04.003" @default.
• W2078047319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25930987" @default.
• W2078047319 hasPublicationYear "2015" @default.
• W2078047319 type Work @default.
• W2078047319 sameAs 2078047319 @default.
• W2078047319 citedByCount "17" @default.
• W2078047319 countsByYear W20780473192016 @default.
• W2078047319 countsByYear W20780473192017 @default.
• W2078047319 countsByYear W20780473192018 @default.
• W2078047319 countsByYear W20780473192019 @default.
• W2078047319 countsByYear W20780473192020 @default.
• W2078047319 countsByYear W20780473192021 @default.
• W2078047319 countsByYear W20780473192022 @default.
• W2078047319 countsByYear W20780473192023 @default.
• W2078047319 crossrefType "journal-article" @default.
• W2078047319 hasAuthorship W2078047319A5017655268 @default.
• W2078047319 hasAuthorship W2078047319A5036663494 @default.
• W2078047319 hasAuthorship W2078047319A5044487476 @default.
• W2078047319 hasAuthorship W2078047319A5048499185 @default.
• W2078047319 hasAuthorship W2078047319A5048661242 @default.
• W2078047319 hasAuthorship W2078047319A5056121017 @default.
• W2078047319 hasAuthorship W2078047319A5058976153 @default.
• W2078047319 hasAuthorship W2078047319A5063872688 @default.
• W2078047319 hasBestOaLocation W20780473191 @default.
• W2078047319 hasConcept C170493617 @default.
• W2078047319 hasConcept C178790620 @default.
• W2078047319 hasConcept C185592680 @default.
• W2078047319 hasConcept C2777884321 @default.
• W2078047319 hasConcept C2779281246 @default.
• W2078047319 hasConcept C2779448229 @default.
• W2078047319 hasConcept C2779591629 @default.
• W2078047319 hasConcept C2910159647 @default.

• next