Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078047793> ?p ?o ?g. }
- W2078047793 abstract "Insufficient ATP production relative to cellular requirements is the key factor detrimental to neurons in neurological disorders associated with deficient oxygen/glucose supply or mitochondrial dysfunction. As a large part of the energy consumed by brain cells is used to maintain the Na+ gradient across the cellular membrane, reduction of energy demand by down-modulation of voltage-gated Na+-channels is a rational strategy for neuroprotection against these conditions. Preservation of the inward Na+ gradient is likely to be also beneficial as it is an essential driving force for vital ion exchanges and transport mechanisms (e.g. Ca2+-homeostasis and cell volume regulation). From these elements, I propose that use-dependent Na+-channel blockers increase the resilience of nerve cells to the primary insult and/or subsequent deleterious events, and that reduced efflux of glutamate and other compounds is only a consequence of cellular stress attenuation. The widespread hypothesis that down-modulation of Na+-channels is neuroprotective primarily through reduction of presynaptic glutamate release conflicts with strong experimental evidence." @default.
- W2078047793 created "2016-06-24" @default.
- W2078047793 creator A5035263421 @default.
- W2078047793 date "1998-01-01" @default.
- W2078047793 modified "2023-09-24" @default.
- W2078047793 title "Neuroprotective Strategies: Voltage-Gated Na+-Channel Down-Modulation versus Presynaptic Glutamate Release Inhibition" @default.
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- W2078047793 doi "https://doi.org/10.1515/revneuro.1998.9.3.203" @default.
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