Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078049593> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2078049593 endingPage "78" @default.
- W2078049593 startingPage "77" @default.
- W2078049593 abstract "Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) which deregulates cyclin D1. Small subsets of cases have been identified with variant CCND1 translocations with the immunoglobulin light chain genes or with alternative translocations involving CCND2 and CCND3. Additionally, double-hit MCL with MYC rearrangements with a highly aggressive clinical course have been reported, but no other frequent recurrent translocations have been identified. In recent years, genome-wide screening of copy number alterations by comparative genomic hybridization and genomic microarray platforms have revealed a characteristic MCL profile of multiple secondary gains and losses as well as regions of copy number neutral loss of heterozygosity that target mainly genes involved in cell cycle regulation, DNA damage response, and cell survival pathways. Several aberrations have been found to be associated with worse prognosis, 3q gains and losses of 8p, 9p, and 17p. An increased number of secondary alterations and blastoid morphology have also been shown to be associated with cases with short survival. On the contrary, indolent MCL cases carry only the primary t(11;14) and few or no other additional genomic alterations. Altogether these observations suggest that the genetic background of MCL is an important factor that dictates their different clinical behavior. This review will focus on MCL from a genetic perspective and will present next-generation sequencing technology as a new potential tool to complement the study of complex genomes. The better understanding of genetic alterations of MCL may offer new approaches for more patient-tailored, risk-adapted treatment options." @default.
- W2078049593 created "2016-06-24" @default.
- W2078049593 creator A5005683145 @default.
- W2078049593 creator A5012684686 @default.
- W2078049593 creator A5013639072 @default.
- W2078049593 creator A5014700415 @default.
- W2078049593 creator A5081561534 @default.
- W2078049593 creator A5083533427 @default.
- W2078049593 date "2008-07-01" @default.
- W2078049593 modified "2023-10-18" @default.
- W2078049593 title "Up-regulation of thymosin β4 is a determinant of the transformed phenotype and invasiveness of mouse fibrosarcoma cells" @default.
- W2078049593 doi "https://doi.org/10.1016/s1359-6349(08)71473-3" @default.
- W2078049593 hasPublicationYear "2008" @default.
- W2078049593 type Work @default.
- W2078049593 sameAs 2078049593 @default.
- W2078049593 citedByCount "0" @default.
- W2078049593 crossrefType "journal-article" @default.
- W2078049593 hasAuthorship W2078049593A5005683145 @default.
- W2078049593 hasAuthorship W2078049593A5012684686 @default.
- W2078049593 hasAuthorship W2078049593A5013639072 @default.
- W2078049593 hasAuthorship W2078049593A5014700415 @default.
- W2078049593 hasAuthorship W2078049593A5081561534 @default.
- W2078049593 hasAuthorship W2078049593A5083533427 @default.
- W2078049593 hasConcept C104317684 @default.
- W2078049593 hasConcept C120821319 @default.
- W2078049593 hasConcept C124942203 @default.
- W2078049593 hasConcept C127716648 @default.
- W2078049593 hasConcept C138626823 @default.
- W2078049593 hasConcept C141231307 @default.
- W2078049593 hasConcept C143589142 @default.
- W2078049593 hasConcept C150194340 @default.
- W2078049593 hasConcept C180754005 @default.
- W2078049593 hasConcept C186836561 @default.
- W2078049593 hasConcept C203014093 @default.
- W2078049593 hasConcept C2775912362 @default.
- W2078049593 hasConcept C2777525834 @default.
- W2078049593 hasConcept C2779338263 @default.
- W2078049593 hasConcept C502942594 @default.
- W2078049593 hasConcept C54355233 @default.
- W2078049593 hasConcept C70721500 @default.
- W2078049593 hasConcept C86803240 @default.
- W2078049593 hasConceptScore W2078049593C104317684 @default.
- W2078049593 hasConceptScore W2078049593C120821319 @default.
- W2078049593 hasConceptScore W2078049593C124942203 @default.
- W2078049593 hasConceptScore W2078049593C127716648 @default.
- W2078049593 hasConceptScore W2078049593C138626823 @default.
- W2078049593 hasConceptScore W2078049593C141231307 @default.
- W2078049593 hasConceptScore W2078049593C143589142 @default.
- W2078049593 hasConceptScore W2078049593C150194340 @default.
- W2078049593 hasConceptScore W2078049593C180754005 @default.
- W2078049593 hasConceptScore W2078049593C186836561 @default.
- W2078049593 hasConceptScore W2078049593C203014093 @default.
- W2078049593 hasConceptScore W2078049593C2775912362 @default.
- W2078049593 hasConceptScore W2078049593C2777525834 @default.
- W2078049593 hasConceptScore W2078049593C2779338263 @default.
- W2078049593 hasConceptScore W2078049593C502942594 @default.
- W2078049593 hasConceptScore W2078049593C54355233 @default.
- W2078049593 hasConceptScore W2078049593C70721500 @default.
- W2078049593 hasConceptScore W2078049593C86803240 @default.
- W2078049593 hasIssue "9" @default.
- W2078049593 hasLocation W20780495931 @default.
- W2078049593 hasOpenAccess W2078049593 @default.
- W2078049593 hasPrimaryLocation W20780495931 @default.
- W2078049593 hasRelatedWork W1973420710 @default.
- W2078049593 hasRelatedWork W2002580394 @default.
- W2078049593 hasRelatedWork W2003922337 @default.
- W2078049593 hasRelatedWork W2006031664 @default.
- W2078049593 hasRelatedWork W2081906057 @default.
- W2078049593 hasRelatedWork W2116902981 @default.
- W2078049593 hasRelatedWork W2120174899 @default.
- W2078049593 hasRelatedWork W2548862834 @default.
- W2078049593 hasRelatedWork W2924957354 @default.
- W2078049593 hasRelatedWork W2952404323 @default.
- W2078049593 hasVolume "6" @default.
- W2078049593 isParatext "false" @default.
- W2078049593 isRetracted "false" @default.
- W2078049593 magId "2078049593" @default.
- W2078049593 workType "article" @default.