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• W2078051927 startingPage "2809" @default.
• W2078051927 abstract "Abstract Angiotensin-(1-7) [Ang-(1-7)] is an endogenous peptide of the renin-angiotensin system with vasodilator and antiproliferative properties. Our previous studies showed that Ang-(1-7) reduced serum-stimulated growth of human lung cancer cells in vitro through activation of a unique AT(1-7) receptor. The current study investigates the effect of Ang-(1-7) on lung tumor growth in vivo, using a human lung tumor xenograft model. Athymic mice with tumors resulting from injection of A549 human lung cancer cells were treated for 28 days with either i.v. saline or Ang-(1-7), delivered by implanted osmotic mini-pumps. Treatment with Ang-(1-7) reduced tumor volume by 30% compared with the size before treatment; in contrast, tumor size in the saline-treated animals increased 2.5-fold. These results correlate with a reduction in the proliferation marker Ki67 in the Ang-(1-7)–infused tumors when compared with the saline-infused tumor tissues. Treatment with Ang-(1-7) significantly reduced cyclooxygenase-2 (COX-2) mRNA and protein in tumors of Ang-(1-7)–infused mice when compared with mice treated with saline as well as in the parent A549 human lung cancer cells in tissue culture. These results suggest that Ang-(1-7) may decrease COX-2 activity and proinflammatory prostaglandins to inhibit lung tumor growth. In contrast, the heptapeptide had no effect on COX-1 mRNA in xenograft tumors or A549 cells. Because Ang-(1-7), a peptide with antithrombotic properties, reduces growth through activation of a selective AT(1-7) receptor, our results suggest that the heptapeptide represents a novel treatment for lung cancer by reducing COX-2. [Cancer Res 2007;67(6):2809–15]" @default.
• W2078051927 created "2016-06-24" @default.
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• W2078051927 date "2007-03-15" @default.
• W2078051927 modified "2023-09-27" @default.
• W2078051927 title "Angiotensin-(1-7) Inhibits Growth of Human Lung Adenocarcinoma Xenografts in Nude Mice through a Reduction in Cyclooxygenase-2" @default.
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• W2078051927 doi "https://doi.org/10.1158/0008-5472.can-06-3614" @default.
• W2078051927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17363603" @default.
• W2078051927 hasPublicationYear "2007" @default.
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