FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078056589> ?p ?o ?g. }

• W2078056589 endingPage "575" @default.
• W2078056589 startingPage "575" @default.
• W2078056589 abstract "The use of biologically active compounds isolated from edible mushrooms against cancer raises global interest. Anticancer properties are mainly attributed to biopolymers including mainly polysaccharides, polysaccharopeptides, polysaccharide proteins, glycoproteins and proteins. In spite of the fact that Boletus edulis is one of the widely occurring and most consumed edible mushrooms, antitumor biopolymers isolated from it have not been exactly defined and studied so far. The present study is an attempt to extend this knowledge on molecular mechanisms of their anticancer action. The mushroom biopolymers (polysaccharides and glycoproteins) were extracted with hot water and purified by anion-exchange chromatography. The antiproliferative activity in human colon adenocarcinoma cells (LS180) was screened by means of MTT and BrdU assays. At the same time fractions' cytotoxicity was examined on the human colon epithelial cells (CCD 841 CoTr) by means of the LDH assay. Flow cytometry and Western blotting were applied to cell cycle analysis and protein expression involved in anticancer activity of the selected biopolymer fraction. In vitro studies have shown that fractions isolated from Boletus edulis were not toxic against normal colon epithelial cells and in the same concentration range elicited a very prominent antiproliferative effect in colon cancer cells. The best results were obtained in the case of the fraction designated as BE3. The tested compound inhibited cancer cell proliferation which was accompanied by cell cycle arrest in the G0/G1-phase. Growth inhibition was associated with modulation of the p16/cyclin D1/CDK4-6/pRb pathway, an aberration of which is a critical step in the development of many human cancers including colon cancer. Our results indicate that a biopolymer BE3 from Boletus edulis possesses anticancer potential and may provide a new therapeutic/preventive option in colon cancer chemoprevention." @default.
• W2078056589 created "2016-06-24" @default.
• W2078056589 creator A5016175037 @default.
• W2078056589 creator A5024359340 @default.
• W2078056589 creator A5026993496 @default.
• W2078056589 creator A5048682606 @default.
• W2078056589 creator A5051225609 @default.
• W2078056589 creator A5056447505 @default.
• W2078056589 creator A5081115781 @default.
• W2078056589 date "2013-01-01" @default.
• W2078056589 modified "2023-10-18" @default.
• W2078056589 title "Boletus edulis biologically active biopolymers induce cell cycle arrest in human colon adenocarcinoma cells" @default.
• W2078056589 cites W1005258775 @default.
• W2078056589 cites W1813513289 @default.
• W2078056589 cites W1965606913 @default.
• W2078056589 cites W1972771095 @default.
• W2078056589 cites W1977445162 @default.
• W2078056589 cites W1982621844 @default.
• W2078056589 cites W1993494763 @default.
• W2078056589 cites W1997813173 @default.
• W2078056589 cites W2009291628 @default.
• W2078056589 cites W2027928112 @default.
• W2078056589 cites W2041814940 @default.
• W2078056589 cites W2066505604 @default.
• W2078056589 cites W2071491495 @default.
• W2078056589 cites W2080961798 @default.
• W2078056589 cites W2082722418 @default.
• W2078056589 cites W2086262043 @default.
• W2078056589 cites W2098622645 @default.
• W2078056589 cites W2111420633 @default.
• W2078056589 cites W2121878520 @default.
• W2078056589 cites W2143251952 @default.
• W2078056589 cites W2146787709 @default.
• W2078056589 cites W2150111959 @default.
• W2078056589 cites W2155740757 @default.
• W2078056589 cites W2158764247 @default.
• W2078056589 cites W2160340008 @default.
• W2078056589 cites W2165805008 @default.
• W2078056589 cites W259156176 @default.
• W2078056589 cites W4246994209 @default.
• W2078056589 doi "https://doi.org/10.1039/c2fo30324h" @default.
• W2078056589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23370594" @default.
• W2078056589 hasPublicationYear "2013" @default.
• W2078056589 type Work @default.
• W2078056589 sameAs 2078056589 @default.
• W2078056589 citedByCount "34" @default.
• W2078056589 countsByYear W20780565892013 @default.
• W2078056589 countsByYear W20780565892014 @default.
• W2078056589 countsByYear W20780565892015 @default.
• W2078056589 countsByYear W20780565892016 @default.
• W2078056589 countsByYear W20780565892017 @default.
• W2078056589 countsByYear W20780565892018 @default.
• W2078056589 countsByYear W20780565892019 @default.
• W2078056589 countsByYear W20780565892020 @default.
• W2078056589 countsByYear W20780565892021 @default.
• W2078056589 countsByYear W20780565892022 @default.
• W2078056589 countsByYear W20780565892023 @default.
• W2078056589 crossrefType "journal-article" @default.
• W2078056589 hasAuthorship W2078056589A5016175037 @default.
• W2078056589 hasAuthorship W2078056589A5024359340 @default.
• W2078056589 hasAuthorship W2078056589A5026993496 @default.
• W2078056589 hasAuthorship W2078056589A5048682606 @default.
• W2078056589 hasAuthorship W2078056589A5051225609 @default.
• W2078056589 hasAuthorship W2078056589A5056447505 @default.
• W2078056589 hasAuthorship W2078056589A5081115781 @default.
• W2078056589 hasConcept C100817775 @default.
• W2078056589 hasConcept C105696609 @default.
• W2078056589 hasConcept C109316439 @default.
• W2078056589 hasConcept C116073593 @default.
• W2078056589 hasConcept C1491633281 @default.
• W2078056589 hasConcept C153911025 @default.
• W2078056589 hasConcept C185592680 @default.
• W2078056589 hasConcept C199835354 @default.
• W2078056589 hasConcept C202751555 @default.
• W2078056589 hasConcept C2776474821 @default.
• W2078056589 hasConcept C2779473724 @default.
• W2078056589 hasConcept C2780783641 @default.
• W2078056589 hasConcept C29537977 @default.
• W2078056589 hasConcept C31903555 @default.
• W2078056589 hasConcept C553184892 @default.
• W2078056589 hasConcept C55493867 @default.
• W2078056589 hasConcept C62112901 @default.
• W2078056589 hasConcept C86803240 @default.
• W2078056589 hasConceptScore W2078056589C100817775 @default.
• W2078056589 hasConceptScore W2078056589C105696609 @default.
• W2078056589 hasConceptScore W2078056589C109316439 @default.
• W2078056589 hasConceptScore W2078056589C116073593 @default.
• W2078056589 hasConceptScore W2078056589C1491633281 @default.
• W2078056589 hasConceptScore W2078056589C153911025 @default.
• W2078056589 hasConceptScore W2078056589C185592680 @default.
• W2078056589 hasConceptScore W2078056589C199835354 @default.
• W2078056589 hasConceptScore W2078056589C202751555 @default.
• W2078056589 hasConceptScore W2078056589C2776474821 @default.
• W2078056589 hasConceptScore W2078056589C2779473724 @default.
• W2078056589 hasConceptScore W2078056589C2780783641 @default.
• W2078056589 hasConceptScore W2078056589C29537977 @default.
• W2078056589 hasConceptScore W2078056589C31903555 @default.
• W2078056589 hasConceptScore W2078056589C553184892 @default.

• next