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• W2078058404 abstract "A series of analogs of GLP-1(7-36) amide containing a Nepsilon-(2-[2-[2-(3-maleimidopropylamido)ethoxy]ethoxy]acetyl)lysine has been synthesized and the resulting derivatives were bioconjugated to Cys34 of human serum albumin (HSA). The GLP-1-HSA bioconjugates were analyzed in vitro to assess the stabilizing effect of bioconjugation in the presence of DPP-IV as well as GLP-1 receptor binding and activation. Compound 9 (CJC-1131) having the point of attachment to albumin at the C-terminal of GLP-1 and a D-alanine substitution at position 8 was identified as having the best combination of stability and bioactivity." @default.
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• W2078058404 date "2004-09-01" @default.
• W2078058404 modified "2023-10-15" @default.
• W2078058404 title "Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7–36) analog" @default.
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• W2078058404 doi "https://doi.org/10.1016/j.bmcl.2004.06.066" @default.
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