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• W2078059986 abstract "N-Alkyl and N,N-dialkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P (ADGP) were synthesized and found to inhibit growth of human pathogenic fungi (MICs in the 0.08-0.625mgmL(-1) range for the most active compounds). It was thus shown that N-alkylation of ADGP provides novel inhibitors of a fungal enzyme, glucosamine-6P synthase, exhibiting higher antifungal activity than the parent compound, due to the increased lipophilicity and better uptake by fungal cells." @default.
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• W2078059986 date "2007-12-01" @default.
• W2078059986 modified "2023-10-14" @default.
• W2078059986 title "Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents" @default.
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• W2078059986 doi "https://doi.org/10.1016/j.bmcl.2007.09.072" @default.
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