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- W2078064440 abstract "Clinical interpretation of the compound muscle action potential (CMAP) requires a precise understanding of its underlying mechanisms. We recorded normal thenar CMAPs and motor unit action potentials using different electrode configurations and different thumb positions. Computer simulations show that the CMAP has four parts: rising edge, negative phase, positive phase, and tail, which correspond to four distinct stages of electrical activity in the muscle: initiation at the end-plate, propagation, termination at the muscle/tendon junctions, and slow repolarization. The shapes of volume-conducted signals recorded beyond the muscle are also explained by these four stages. Changes in CMAP shape associated with thumb abduction are due to changes in termination times resulting from changes in muscle-fiber lengths. These findings demonstrate that the negative and positive phases of the CMAP are due to different mechanisms, and that anatomical factors, particularly muscle-fiber lengths, play an important role in determining CMAP shape. © 1996 John Wiley & Sons, Inc." @default.
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- W2078064440 date "1996-11-01" @default.
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- W2078064440 title "Anatomical and electrophysiological determinants of the human thenar compound muscle action potential" @default.
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- W2078064440 doi "https://doi.org/10.1002/(sici)1097-4598(199611)19:11<1457::aid-mus10>3.0.co;2-q" @default.
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