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- W2078066211 abstract "Recent molecular cloning studies have established the existence of a third rat galanin receptor subtype, GalR3, however its precise distribution in the mammalian central nervous system (CNS) is not well established. In the present study, we examined the regional and cellular distribution of GalR3 mRNA in the CNS of the rat by in situ hybridization. Our findings indicate that GALR3 mRNA expression in the rat brain is discrete and highly restricted, concentrated mainly in the preoptic/hypothalamic area. Within the hypothalamus, GalR3 expression was confined to the paraventricular, ventromedial and dorsomedial hypothalamic nuclei. In addition to these hypothalamic nuclei, GalR3 mRNA-expressing cells were observed in the medial septum/diagonal band of Broca complex, the bed nucleus of the stria terminalis, the medial amygdaloid nucleus, the periaqueductal gray, the lateral parabrachial nucleus, the dorsal raphe nucleus, the locus coeruleus, the medial medullary reticular formation and in one of the circumventricular organs, the subfornical organ. In the spinal cord, a faint but specific ISH signal was observed over the laminae I-II with a few moderately labeled cells distributed in laminae V and X. The neuroanatomical distribution of GalR3 suggests it might be involved in mediating documented effects of galanin on food intake, fluid homeostasis, cardiovascular function and nociception." @default.
- W2078066211 created "2016-06-24" @default.
- W2078066211 creator A5010077476 @default.
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- W2078066211 creator A5041884090 @default.
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- W2078066211 date "2002-11-01" @default.
- W2078066211 modified "2023-09-25" @default.
- W2078066211 title "Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system" @default.
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- W2078066211 doi "https://doi.org/10.1016/s0891-0618(02)00068-6" @default.
- W2078066211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12406501" @default.
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