Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078079917> ?p ?o ?g. }
- W2078079917 endingPage "52" @default.
- W2078079917 startingPage "41" @default.
- W2078079917 abstract "Summary Resistance to chemotherapy and drug toxicity are two major concerns of chronic lymphocytic leukaemia (B‐CLL) treatment by purine nucleoside analogues (PNA, i.e. fludarabine and cladribine). We hypothesized that targeting epigenetic changes might address these issues and evaluated the effect of the histone deacetylase inhibitor valproate (VPA) at a clinically relevant concentration. VPA acted in a highly synergistic/additive manner with fludarabine and cladribine to induce apoptosis of B‐CLL cells. Importantly, VPA also restored sensitivity to fludarabine in B cells from poor prognosis CLL patients who became resistant to chemotherapy. Mechanism of apoptosis induced by VPA alone or combined with fludarabine or to cladribine was caspase‐dependent and involved the extrinsic pathway. VPA, but neither fludarabine nor cladribine, enhanced the production of reactive oxygen species (ROS) and inhibition of ROS with N ‐acetylcysteine decreases apoptosis of CLL cells. VPA stimulates hyperphosphorylation of p42/p44 ERK, cytochrome c release and overexpression of Bax and Fas. Together, our data indicate that VPA may ameliorate the outcome of PNA‐based therapeutic protocols and provide a potential alternative treatment in both the relapsed and front‐line resistant patients and in patients with high risk features." @default.
- W2078079917 created "2016-06-24" @default.
- W2078079917 creator A5006564157 @default.
- W2078079917 creator A5014328808 @default.
- W2078079917 creator A5025678898 @default.
- W2078079917 creator A5034397098 @default.
- W2078079917 creator A5038573838 @default.
- W2078079917 creator A5042997291 @default.
- W2078079917 creator A5044001238 @default.
- W2078079917 creator A5051999451 @default.
- W2078079917 creator A5053031492 @default.
- W2078079917 creator A5060368506 @default.
- W2078079917 creator A5074992319 @default.
- W2078079917 creator A5075200393 @default.
- W2078079917 creator A5079634926 @default.
- W2078079917 date "2008-12-09" @default.
- W2078079917 modified "2023-10-17" @default.
- W2078079917 title "Valproate synergizes with purine nucleoside analogues to induce apoptosis of B‐chronic lymphocytic leukaemia cells" @default.
- W2078079917 cites W146673805 @default.
- W2078079917 cites W1484293540 @default.
- W2078079917 cites W1906996655 @default.
- W2078079917 cites W1973736602 @default.
- W2078079917 cites W1974090542 @default.
- W2078079917 cites W1978835020 @default.
- W2078079917 cites W1989186104 @default.
- W2078079917 cites W1992740422 @default.
- W2078079917 cites W1993712190 @default.
- W2078079917 cites W1996318087 @default.
- W2078079917 cites W2000225649 @default.
- W2078079917 cites W2004980848 @default.
- W2078079917 cites W2010140285 @default.
- W2078079917 cites W2012620089 @default.
- W2078079917 cites W2015120596 @default.
- W2078079917 cites W2017102177 @default.
- W2078079917 cites W2018172208 @default.
- W2078079917 cites W2018976177 @default.
- W2078079917 cites W2031954417 @default.
- W2078079917 cites W2034076446 @default.
- W2078079917 cites W2035396217 @default.
- W2078079917 cites W2038105958 @default.
- W2078079917 cites W2048289333 @default.
- W2078079917 cites W2072514745 @default.
- W2078079917 cites W2081490747 @default.
- W2078079917 cites W2093264973 @default.
- W2078079917 cites W2094043001 @default.
- W2078079917 cites W2106357158 @default.
- W2078079917 cites W2114001234 @default.
- W2078079917 cites W2117648265 @default.
- W2078079917 cites W2117691193 @default.
- W2078079917 cites W2125134816 @default.
- W2078079917 cites W2125483185 @default.
- W2078079917 cites W2131331729 @default.
- W2078079917 cites W2136494061 @default.
- W2078079917 cites W2137804513 @default.
- W2078079917 cites W2140215067 @default.
- W2078079917 cites W2145632083 @default.
- W2078079917 cites W2154256241 @default.
- W2078079917 cites W2158463669 @default.
- W2078079917 cites W2159887704 @default.
- W2078079917 cites W2275948481 @default.
- W2078079917 cites W2333828318 @default.
- W2078079917 cites W4231182068 @default.
- W2078079917 cites W4235838915 @default.
- W2078079917 cites W4241741898 @default.
- W2078079917 cites W61714529 @default.
- W2078079917 cites W96780237 @default.
- W2078079917 doi "https://doi.org/10.1111/j.1365-2141.2008.07426.x" @default.
- W2078079917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19006566" @default.
- W2078079917 hasPublicationYear "2008" @default.
- W2078079917 type Work @default.
- W2078079917 sameAs 2078079917 @default.
- W2078079917 citedByCount "47" @default.
- W2078079917 countsByYear W20780799172012 @default.
- W2078079917 countsByYear W20780799172013 @default.
- W2078079917 countsByYear W20780799172014 @default.
- W2078079917 countsByYear W20780799172015 @default.
- W2078079917 countsByYear W20780799172016 @default.
- W2078079917 countsByYear W20780799172019 @default.
- W2078079917 countsByYear W20780799172020 @default.
- W2078079917 crossrefType "journal-article" @default.
- W2078079917 hasAuthorship W2078079917A5006564157 @default.
- W2078079917 hasAuthorship W2078079917A5014328808 @default.
- W2078079917 hasAuthorship W2078079917A5025678898 @default.
- W2078079917 hasAuthorship W2078079917A5034397098 @default.
- W2078079917 hasAuthorship W2078079917A5038573838 @default.
- W2078079917 hasAuthorship W2078079917A5042997291 @default.
- W2078079917 hasAuthorship W2078079917A5044001238 @default.
- W2078079917 hasAuthorship W2078079917A5051999451 @default.
- W2078079917 hasAuthorship W2078079917A5053031492 @default.
- W2078079917 hasAuthorship W2078079917A5060368506 @default.
- W2078079917 hasAuthorship W2078079917A5074992319 @default.
- W2078079917 hasAuthorship W2078079917A5075200393 @default.
- W2078079917 hasAuthorship W2078079917A5079634926 @default.
- W2078079917 hasConcept C104317684 @default.
- W2078079917 hasConcept C109246011 @default.
- W2078079917 hasConcept C126322002 @default.
- W2078079917 hasConcept C181199279 @default.
- W2078079917 hasConcept C185592680 @default.