FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078084207> ?p ?o ?g. }

• W2078084207 endingPage "70" @default.
• W2078084207 startingPage "66" @default.
• W2078084207 abstract "Alternative splicing (AS) is a common phenomenon in gene expression of eukaryotic organisms, especially in mammals, producing multiple gene isoforms from a single gene that involve in physiological and pathological processes. Receptor for advanced glycation end products (RAGE) has multiple AS isoforms with significant tissue and organism specificity. RAGE signaling has been reported involved in the onset and development of Alzheimer's disease (AD) and the roles of RAGE AS isoforms have not yet been fully illustrated in AD pathogenesis. In the present study, two of RAGE AS isoforms (RAGEΔ and sRAGEΔ) were investigated in the human brain specimens from AD and age-matched control subjects. The expression of these isoforms was found brain-region specific, and significant lower expression levels of both RAGEΔ and sRAGEΔ were detected in multiple brain regions of AD subjects than control subjects. Data indicated tight association between the AS isoforms (RAGEΔ and sRAGEΔ) and neurodegeneration. An antagonistic pairing model has been suggested to explain the working mechanism of AS isoforms on gene regulation and pathological development." @default.
• W2078084207 created "2016-06-24" @default.
• W2078084207 creator A5008786007 @default.
• W2078084207 creator A5013418213 @default.
• W2078084207 date "2015-06-01" @default.
• W2078084207 modified "2023-09-27" @default.
• W2078084207 title "Lower expression level of two RAGE alternative splicing isoforms in Alzheimer’s disease" @default.
• W2078084207 cites W1604205666 @default.
• W2078084207 cites W1965195669 @default.
• W2078084207 cites W1982797011 @default.
• W2078084207 cites W1985327918 @default.
• W2078084207 cites W2007771347 @default.
• W2078084207 cites W2011920499 @default.
• W2078084207 cites W2012681341 @default.
• W2078084207 cites W2027183895 @default.
• W2078084207 cites W2049167261 @default.
• W2078084207 cites W2054082659 @default.
• W2078084207 cites W2062273929 @default.
• W2078084207 cites W2065326233 @default.
• W2078084207 cites W2073714833 @default.
• W2078084207 cites W2082119527 @default.
• W2078084207 cites W2094702605 @default.
• W2078084207 cites W2105678207 @default.
• W2078084207 cites W2118385532 @default.
• W2078084207 cites W2128239740 @default.
• W2078084207 cites W2138953837 @default.
• W2078084207 cites W2139891639 @default.
• W2078084207 cites W2146122014 @default.
• W2078084207 cites W2155804510 @default.
• W2078084207 cites W2170752851 @default.
• W2078084207 cites W2239614455 @default.
• W2078084207 doi "https://doi.org/10.1016/j.neulet.2015.04.032" @default.
• W2078084207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25912778" @default.
• W2078084207 hasPublicationYear "2015" @default.
• W2078084207 type Work @default.
• W2078084207 sameAs 2078084207 @default.
• W2078084207 citedByCount "10" @default.
• W2078084207 countsByYear W20780842072016 @default.
• W2078084207 countsByYear W20780842072017 @default.
• W2078084207 countsByYear W20780842072018 @default.
• W2078084207 countsByYear W20780842072019 @default.
• W2078084207 countsByYear W20780842072020 @default.
• W2078084207 countsByYear W20780842072023 @default.
• W2078084207 crossrefType "journal-article" @default.
• W2078084207 hasAuthorship W2078084207A5008786007 @default.
• W2078084207 hasAuthorship W2078084207A5013418213 @default.
• W2078084207 hasConcept C104317684 @default.
• W2078084207 hasConcept C126322002 @default.
• W2078084207 hasConcept C147990577 @default.
• W2078084207 hasConcept C150194340 @default.
• W2078084207 hasConcept C169760540 @default.
• W2078084207 hasConcept C170493617 @default.
• W2078084207 hasConcept C194583182 @default.
• W2078084207 hasConcept C203014093 @default.
• W2078084207 hasConcept C2776925932 @default.
• W2078084207 hasConcept C2778857457 @default.
• W2078084207 hasConcept C2779134260 @default.
• W2078084207 hasConcept C2780942790 @default.
• W2078084207 hasConcept C502032728 @default.
• W2078084207 hasConcept C53345823 @default.
• W2078084207 hasConcept C54355233 @default.
• W2078084207 hasConcept C71924100 @default.
• W2078084207 hasConcept C86803240 @default.
• W2078084207 hasConcept C95444343 @default.
• W2078084207 hasConceptScore W2078084207C104317684 @default.
• W2078084207 hasConceptScore W2078084207C126322002 @default.
• W2078084207 hasConceptScore W2078084207C147990577 @default.
• W2078084207 hasConceptScore W2078084207C150194340 @default.
• W2078084207 hasConceptScore W2078084207C169760540 @default.
• W2078084207 hasConceptScore W2078084207C170493617 @default.
• W2078084207 hasConceptScore W2078084207C194583182 @default.
• W2078084207 hasConceptScore W2078084207C203014093 @default.
• W2078084207 hasConceptScore W2078084207C2776925932 @default.
• W2078084207 hasConceptScore W2078084207C2778857457 @default.
• W2078084207 hasConceptScore W2078084207C2779134260 @default.
• W2078084207 hasConceptScore W2078084207C2780942790 @default.
• W2078084207 hasConceptScore W2078084207C502032728 @default.
• W2078084207 hasConceptScore W2078084207C53345823 @default.
• W2078084207 hasConceptScore W2078084207C54355233 @default.
• W2078084207 hasConceptScore W2078084207C71924100 @default.
• W2078084207 hasConceptScore W2078084207C86803240 @default.
• W2078084207 hasConceptScore W2078084207C95444343 @default.
• W2078084207 hasLocation W20780842071 @default.
• W2078084207 hasLocation W20780842072 @default.
• W2078084207 hasOpenAccess W2078084207 @default.
• W2078084207 hasPrimaryLocation W20780842071 @default.
• W2078084207 hasRelatedWork W1977020283 @default.
• W2078084207 hasRelatedWork W2027819189 @default.
• W2078084207 hasRelatedWork W2044505313 @default.
• W2078084207 hasRelatedWork W2078084207 @default.
• W2078084207 hasRelatedWork W2078213156 @default.
• W2078084207 hasRelatedWork W2329901834 @default.
• W2078084207 hasRelatedWork W2359791178 @default.
• W2078084207 hasRelatedWork W2413495522 @default.
• W2078084207 hasRelatedWork W2980579975 @default.
• W2078084207 hasRelatedWork W3164840782 @default.
• W2078084207 hasVolume "597" @default.
• W2078084207 isParatext "false" @default.

• next