FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078086703> ?p ?o ?g. }

• W2078086703 endingPage "85" @default.
• W2078086703 startingPage "77" @default.
• W2078086703 abstract "Neuroferritinopathies are dominantly inherited movement disorders associated with nucleotide insertions in the L-ferritin gene that modify the protein's C-terminus. The insertions alter physical and functional properties of the ferritins, causing an imbalance in brain iron homeostasis. We describe the effects produced by the over-expression in HeLa and neuroblastoma SH-SY5Y cells of two pathogenic L-ferritin variants, 460InsA and 498InsTC. Both peptides co-assembled with endogenous ferritins, producing molecules with reduced iron incorporation capacity, acting in a dominant negative manner. The cells showed an increase in cell death and a decrease in proteasomal activity. The formation of iron-ferritin aggregates became evident after 10 days of variant expression and was not associated with increased cell death. The addition of iron chelators or antioxidants restored proteasomal activity and reduced aggregate formation. The data indicate that cellular iron imbalance and oxidative damage are primary causes of cell death, while aggregate formation is a secondary effect." @default.
• W2078086703 created "2016-06-24" @default.
• W2078086703 creator A5001560379 @default.
• W2078086703 creator A5034703359 @default.
• W2078086703 creator A5050840680 @default.
• W2078086703 creator A5060062016 @default.
• W2078086703 creator A5072094039 @default.
• W2078086703 creator A5080135320 @default.
• W2078086703 creator A5085464877 @default.
• W2078086703 date "2010-01-01" @default.
• W2078086703 modified "2023-09-24" @default.
• W2078086703 title "Oxidative stress and cell death in cells expressing L-ferritin variants causing neuroferritinopathy" @default.
• W2078086703 cites W1424441722 @default.
• W2078086703 cites W1504183294 @default.
• W2078086703 cites W1519013154 @default.
• W2078086703 cites W1532974216 @default.
• W2078086703 cites W1566969252 @default.
• W2078086703 cites W1589564633 @default.
• W2078086703 cites W1797297565 @default.
• W2078086703 cites W1966352463 @default.
• W2078086703 cites W1967922486 @default.
• W2078086703 cites W1970788371 @default.
• W2078086703 cites W1977203945 @default.
• W2078086703 cites W1982669236 @default.
• W2078086703 cites W2009110155 @default.
• W2078086703 cites W2017360920 @default.
• W2078086703 cites W2024116510 @default.
• W2078086703 cites W2030928461 @default.
• W2078086703 cites W2041740325 @default.
• W2078086703 cites W2048821928 @default.
• W2078086703 cites W2051546400 @default.
• W2078086703 cites W2060087054 @default.
• W2078086703 cites W2062325518 @default.
• W2078086703 cites W2063622796 @default.
• W2078086703 cites W2068006559 @default.
• W2078086703 cites W2072419022 @default.
• W2078086703 cites W2085524884 @default.
• W2078086703 cites W2086567353 @default.
• W2078086703 cites W2090829119 @default.
• W2078086703 cites W2099819774 @default.
• W2078086703 cites W2121926054 @default.
• W2078086703 cites W2136207768 @default.
• W2078086703 cites W2136827920 @default.
• W2078086703 cites W2141802615 @default.
• W2078086703 cites W2147249791 @default.
• W2078086703 cites W2147993424 @default.
• W2078086703 cites W2159677246 @default.
• W2078086703 cites W2314677120 @default.
• W2078086703 cites W40385902 @default.
• W2078086703 cites W4246230178 @default.
• W2078086703 cites W4247785245 @default.
• W2078086703 doi "https://doi.org/10.1016/j.nbd.2009.09.009" @default.
• W2078086703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19781644" @default.
• W2078086703 hasPublicationYear "2010" @default.
• W2078086703 type Work @default.
• W2078086703 sameAs 2078086703 @default.
• W2078086703 citedByCount "67" @default.
• W2078086703 countsByYear W20780867032012 @default.
• W2078086703 countsByYear W20780867032013 @default.
• W2078086703 countsByYear W20780867032014 @default.
• W2078086703 countsByYear W20780867032015 @default.
• W2078086703 countsByYear W20780867032017 @default.
• W2078086703 countsByYear W20780867032018 @default.
• W2078086703 countsByYear W20780867032019 @default.
• W2078086703 countsByYear W20780867032020 @default.
• W2078086703 countsByYear W20780867032021 @default.
• W2078086703 countsByYear W20780867032022 @default.
• W2078086703 countsByYear W20780867032023 @default.
• W2078086703 crossrefType "journal-article" @default.
• W2078086703 hasAuthorship W2078086703A5001560379 @default.
• W2078086703 hasAuthorship W2078086703A5034703359 @default.
• W2078086703 hasAuthorship W2078086703A5050840680 @default.
• W2078086703 hasAuthorship W2078086703A5060062016 @default.
• W2078086703 hasAuthorship W2078086703A5072094039 @default.
• W2078086703 hasAuthorship W2078086703A5080135320 @default.
• W2078086703 hasAuthorship W2078086703A5085464877 @default.
• W2078086703 hasConcept C104317684 @default.
• W2078086703 hasConcept C1491633281 @default.
• W2078086703 hasConcept C150194340 @default.
• W2078086703 hasConcept C16613235 @default.
• W2078086703 hasConcept C185592680 @default.
• W2078086703 hasConcept C190283241 @default.
• W2078086703 hasConcept C2776151105 @default.
• W2078086703 hasConcept C2777366897 @default.
• W2078086703 hasConcept C2778319317 @default.
• W2078086703 hasConcept C2779369046 @default.
• W2078086703 hasConcept C31573885 @default.
• W2078086703 hasConcept C55493867 @default.
• W2078086703 hasConcept C86803240 @default.
• W2078086703 hasConcept C95444343 @default.
• W2078086703 hasConceptScore W2078086703C104317684 @default.
• W2078086703 hasConceptScore W2078086703C1491633281 @default.
• W2078086703 hasConceptScore W2078086703C150194340 @default.
• W2078086703 hasConceptScore W2078086703C16613235 @default.
• W2078086703 hasConceptScore W2078086703C185592680 @default.
• W2078086703 hasConceptScore W2078086703C190283241 @default.
• W2078086703 hasConceptScore W2078086703C2776151105 @default.
• W2078086703 hasConceptScore W2078086703C2777366897 @default.

• next