Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078093304> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2078093304 endingPage "S336" @default.
- W2078093304 startingPage "S335" @default.
- W2078093304 abstract "Pulmonary function post allogeneic hematopoietic stem cell transplant (HSCT) can be impaired by previous exposure to chemotherapy, infection, or graft versus host disease (GVHD). In this retrospective study, we analyzed 21 patients with hematologic malignancies who are long term transplant survivors with a median follow-up of 48 months who had received a related (60%) or unrelated (40%) HSCT conditioned with a busulfan-based regimen. Of 21 patients, 7 are of Caucasian and 14 non-Caucasian ethnicity. All patients had routine pulmonary function tests (PFTs) repeated within two years from transplant and none had underlying lung disease. To eliminate inter-lab variability, all PFTs were performed in the same laboratory. Survival rate at the time of analysis was 90%. We initially compared single parameters of PFTs including corrected diffusion limiting capacity of oxygen (DLCO), forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and total lung capacity (TLC) obtained before and after transplant. Post transplant, all PFT parameters showed some degree of reduction compared to pre-transplant values. FEV1 and FEV1/FVC were significantly decreased (108 vs 92, P = .04 and 86 vs 80%, P = .04, respectively), with no difference between Caucasian and non-Caucasians. Overall, median values of corrected DLCO and TLC prior to and after transplant were only slightly reduced. However, in non-Caucasian patients a significant reduction of DLCO was observed (93%±31 vs 73%±11, P = .05). We analyzed intra-patient changes in DLCO and FEV1 values and no correlation was found between these parameters and the development of chronic GVHD. This study shows an overall decrease in pulmonary function in patients without apparent lung disease following a myeloablative busulfan-based HSCT. However, a higher risk of a reduced DLCO was noted only among non-Caucasian patients. At this time it is not known if this observation is due to genetic, biologic or environmental causes." @default.
- W2078093304 created "2016-06-24" @default.
- W2078093304 creator A5029836748 @default.
- W2078093304 creator A5030174386 @default.
- W2078093304 creator A5039871228 @default.
- W2078093304 creator A5045975962 @default.
- W2078093304 creator A5051815667 @default.
- W2078093304 creator A5054630704 @default.
- W2078093304 creator A5058607156 @default.
- W2078093304 creator A5064773819 @default.
- W2078093304 creator A5082073230 @default.
- W2078093304 date "2013-02-01" @default.
- W2078093304 modified "2023-09-23" @default.
- W2078093304 title "Decreased Pulmonary Function in Asymptomatic Long Term Survivors After Busulfan-Based Myeloablative Allogeneic Hematopoietic Stem Cell Transplant" @default.
- W2078093304 doi "https://doi.org/10.1016/j.bbmt.2012.11.512" @default.
- W2078093304 hasPublicationYear "2013" @default.
- W2078093304 type Work @default.
- W2078093304 sameAs 2078093304 @default.
- W2078093304 citedByCount "0" @default.
- W2078093304 crossrefType "journal-article" @default.
- W2078093304 hasAuthorship W2078093304A5029836748 @default.
- W2078093304 hasAuthorship W2078093304A5030174386 @default.
- W2078093304 hasAuthorship W2078093304A5039871228 @default.
- W2078093304 hasAuthorship W2078093304A5045975962 @default.
- W2078093304 hasAuthorship W2078093304A5051815667 @default.
- W2078093304 hasAuthorship W2078093304A5054630704 @default.
- W2078093304 hasAuthorship W2078093304A5058607156 @default.
- W2078093304 hasAuthorship W2078093304A5064773819 @default.
- W2078093304 hasAuthorship W2078093304A5082073230 @default.
- W2078093304 hasBestOaLocation W20780933041 @default.
- W2078093304 hasConcept C126322002 @default.
- W2078093304 hasConcept C141071460 @default.
- W2078093304 hasConcept C16020263 @default.
- W2078093304 hasConcept C165637977 @default.
- W2078093304 hasConcept C27101514 @default.
- W2078093304 hasConcept C2777408962 @default.
- W2078093304 hasConcept C2777714996 @default.
- W2078093304 hasConcept C2777910003 @default.
- W2078093304 hasConcept C2779972918 @default.
- W2078093304 hasConcept C2780611847 @default.
- W2078093304 hasConcept C2911091166 @default.
- W2078093304 hasConcept C3018587741 @default.
- W2078093304 hasConcept C55520419 @default.
- W2078093304 hasConcept C71924100 @default.
- W2078093304 hasConcept C75603125 @default.
- W2078093304 hasConcept C90924648 @default.
- W2078093304 hasConceptScore W2078093304C126322002 @default.
- W2078093304 hasConceptScore W2078093304C141071460 @default.
- W2078093304 hasConceptScore W2078093304C16020263 @default.
- W2078093304 hasConceptScore W2078093304C165637977 @default.
- W2078093304 hasConceptScore W2078093304C27101514 @default.
- W2078093304 hasConceptScore W2078093304C2777408962 @default.
- W2078093304 hasConceptScore W2078093304C2777714996 @default.
- W2078093304 hasConceptScore W2078093304C2777910003 @default.
- W2078093304 hasConceptScore W2078093304C2779972918 @default.
- W2078093304 hasConceptScore W2078093304C2780611847 @default.
- W2078093304 hasConceptScore W2078093304C2911091166 @default.
- W2078093304 hasConceptScore W2078093304C3018587741 @default.
- W2078093304 hasConceptScore W2078093304C55520419 @default.
- W2078093304 hasConceptScore W2078093304C71924100 @default.
- W2078093304 hasConceptScore W2078093304C75603125 @default.
- W2078093304 hasConceptScore W2078093304C90924648 @default.
- W2078093304 hasIssue "2" @default.
- W2078093304 hasLocation W20780933041 @default.
- W2078093304 hasOpenAccess W2078093304 @default.
- W2078093304 hasPrimaryLocation W20780933041 @default.
- W2078093304 hasRelatedWork W1987138826 @default.
- W2078093304 hasRelatedWork W2078093304 @default.
- W2078093304 hasRelatedWork W2080537680 @default.
- W2078093304 hasRelatedWork W2093247886 @default.
- W2078093304 hasRelatedWork W2100665992 @default.
- W2078093304 hasRelatedWork W2153567950 @default.
- W2078093304 hasRelatedWork W2235325276 @default.
- W2078093304 hasRelatedWork W2351795037 @default.
- W2078093304 hasRelatedWork W2559513675 @default.
- W2078093304 hasRelatedWork W2727721360 @default.
- W2078093304 hasVolume "19" @default.
- W2078093304 isParatext "false" @default.
- W2078093304 isRetracted "false" @default.
- W2078093304 magId "2078093304" @default.
- W2078093304 workType "article" @default.