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• W2078102739 endingPage "S42" @default.
• W2078102739 startingPage "S35" @default.
• W2078102739 abstract "This paper reviews the early features of Rett syndrome (RTT). The behavioral characteristics of RTT were analyzed retrospectively by taking history and asking about early infancy behaviors. The earliest behavioral characteristics are thought to be autistic features and hypotonia of trunkal muscles. Analysis of sleep–wake rhythm and all-night polysomnography suggested that the initial lesion is serotonergic and noradrenargic hypofunction at brainstem level. Dopaminergic (DA) hypofunction associated with DA receptor supersensitivity follows as the brain matures. Characteristic symptoms developing at specific age ranges are based on the neuronal connections of the brainstem aminergic neurons and DA neurons with the pedunculo-pontine nuclei, projecting to specific cortical areas." @default.
• W2078102739 created "2016-06-24" @default.
• W2078102739 creator A5076592756 @default.
• W2078102739 date "2005-11-01" @default.
• W2078102739 modified "2023-10-16" @default.
• W2078102739 title "Early behavior characteristics and sleep disturbance in Rett syndrome" @default.
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• W2078102739 doi "https://doi.org/10.1016/j.braindev.2005.03.017" @default.
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