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- W2078108492 abstract "Aging affects various structural and metabolic properties of the brain. However, associations among various aspects of brain aging are unclear. Moreover, those properties and associations among them may be modified by age-associated increase in vascular risk. In this study, we measured volume of brain regions that vary in their vulnerability to aging and estimated local iron content via T2* relaxometry. In 113 healthy adults (19–83 years old), we examined prefrontal cortex (PFC), primary visual cortex (VC), hippocampus (HC), entorhinal cortex (EC), caudate nucleus (Cd), and putamen (Pt). In some regions (PFC, VC, Cd, and Pt) age-related differences in iron and volume followed similar patterns. However, in the medial–temporal structures, volume and iron content exhibited different age trajectories. Whereas age-related volume reduction was mild in HC and absent in EC, iron content evidenced significant age-related declines. In hypertensive participants significantly greater iron content was noted in all examined regions. Thus, iron content as measured by T2* may be a sensitive index of regional brain aging and may reveal declines that are more prominent than gross anatomical shrinkage." @default.
- W2078108492 created "2016-06-24" @default.
- W2078108492 creator A5050123984 @default.
- W2078108492 creator A5072623234 @default.
- W2078108492 creator A5075845832 @default.
- W2078108492 date "2011-01-01" @default.
- W2078108492 modified "2023-10-16" @default.
- W2078108492 title "Differential effects of age and history of hypertension on regional brain volumes and iron" @default.
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- W2078108492 doi "https://doi.org/10.1016/j.neuroimage.2010.09.068" @default.
- W2078108492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2997191" @default.
- W2078108492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20923707" @default.
- W2078108492 hasPublicationYear "2011" @default.
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