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- W2078110911 abstract "Outer hair cell electromotility, a manifestation of the interconnection between the mechanical and electrical processes occurring in outer hair cells, is believed to be an important contribution to the active cochlea. Two modes of mechanoelectrical coupling in the outer hair cell wall are studied: the potential shift caused by mechanical loading under the wall charge preservation conditions and the current (transferred charge) caused by mechanical loading under the voltage-clamp conditions. By using the previously reported elastic moduli of the wall and components of the active force, the potential shift under the charge preservation conditions is derived. This shift is expressed in terms of the wall strains and the active force derivatives with respect to the wall potential. The magnitudes of the potential shift corresponding to the conditions of cell inflation, axial stretch (compression), and the micropipet aspiration are estimated. In the last case, the distribution of the potential shift along the cell wall is also demonstrated. The potential shift can reach −20–−40 mV under the conditions of the micropipet aspiration or cell inflation. Such shift is much smaller under the condition of cell stretch (compression). The current and the charge transfer caused by the cell stretch under the voltage-clamp conditions is analyzed, and shows good agreement of predictions with experimental data." @default.
- W2078110911 created "2016-06-24" @default.
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- W2078110911 date "2000-03-01" @default.
- W2078110911 modified "2023-09-24" @default.
- W2078110911 title "On the mechanoelectrical coupling in the cochlear outer hair cell" @default.
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- W2078110911 doi "https://doi.org/10.1121/1.428430" @default.
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