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• W2078113045 abstract "Two new natural cycloartanes, tubiferolide methyl ester (1) and tubiferaoctanolide (2), together with the known coronalolide (3) and coronalolide methyl ester (4) have been isolated from leaves and twigs of Gardenia tubifera. In addition, a new flavone 5,3′,5′-trihydroxy-7,4′-dimethoxyflavone (5), five known flavones 6–10 and hexacosyl 4′-hydroxy-trans-cinnamate (11) were also obtained from the same source. The structures were assigned on the basis of spectroscopic methods. Compounds 3, 7, 9, and 10 showed significant cytotoxic activities only in P-388 cell line. Compound 1 was cytotoxic against P-388, KB, Col-2 and Lu-1, while 4 was active in P-388 and BCA-1. Compounds 3 and 4 displayed significant anti-HIV activities in the HIV-1RT assay; compound 7 showed moderate activity in this assay. Compounds 5–10 were also found to be active in the ΔTat/RevMC 99 syncytium assay." @default.
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• W2078113045 date "2004-02-01" @default.
• W2078113045 modified "2023-09-27" @default.
• W2078113045 title "Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera" @default.
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• W2078113045 doi "https://doi.org/10.1016/j.tet.2003.12.010" @default.
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