Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078113353> ?p ?o ?g. }
- W2078113353 endingPage "4245" @default.
- W2078113353 startingPage "4235" @default.
- W2078113353 abstract "Previous studies have implicated fibroblast growth factor receptor 1(FGFR1) in limb development. However, the precise nature and complexity of its role have not been defined. Here, we dissect Fgfr1 function in mouse limb by conditional inactivation of Fgfr1 using two different Cre recombinase-expressing lines. Use of the T (brachyury)-cre line led to Fgfr1 inactivation in all limb bud mesenchyme (LBM) cells during limb initiation. This mutant reveals FGFR1 function in two phases of limb development. In a nascent limb bud, FGFR1 promotes the length of the proximodistal (PD) axis while restricting the dimensions of the other two axes. It also serves an unexpected role in limiting LBM cell number in this early phase. Later on during limb outgrowth, FGFR1 is essential for the expansion of skeletal precursor population by maintaining cell survival. Use of mice carrying the sonic hedgehogcre(Shhcre) allele led to Fgfr1 inactivation in posterior LBM cells. This mutant allows us to test the role of Fgfr1in gene expression regulation without disturbing limb bud growth. Our data show that during autopod patterning, FGFR1 influences digit number and identity, probably through cell-autonomous regulation of Shhexpression. Our study of these two Fgfr1 conditional mutants has elucidated the multiple roles of FGFR1 in limb bud establishment, growth and patterning." @default.
- W2078113353 created "2016-06-24" @default.
- W2078113353 creator A5021331883 @default.
- W2078113353 creator A5027287933 @default.
- W2078113353 creator A5047977465 @default.
- W2078113353 creator A5050911555 @default.
- W2078113353 creator A5058427531 @default.
- W2078113353 date "2005-10-01" @default.
- W2078113353 modified "2023-09-26" @default.
- W2078113353 title "Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning" @default.
- W2078113353 cites W1486948662 @default.
- W2078113353 cites W1575984269 @default.
- W2078113353 cites W1583338361 @default.
- W2078113353 cites W1768274470 @default.
- W2078113353 cites W1828499021 @default.
- W2078113353 cites W1922337323 @default.
- W2078113353 cites W1963643849 @default.
- W2078113353 cites W1970147973 @default.
- W2078113353 cites W1971136975 @default.
- W2078113353 cites W1971943177 @default.
- W2078113353 cites W1978596841 @default.
- W2078113353 cites W1981747964 @default.
- W2078113353 cites W1987485173 @default.
- W2078113353 cites W1990797650 @default.
- W2078113353 cites W1997631325 @default.
- W2078113353 cites W1998880332 @default.
- W2078113353 cites W2002056139 @default.
- W2078113353 cites W2002468669 @default.
- W2078113353 cites W2011257584 @default.
- W2078113353 cites W2015518796 @default.
- W2078113353 cites W2021948683 @default.
- W2078113353 cites W2022285707 @default.
- W2078113353 cites W2027780440 @default.
- W2078113353 cites W2028828556 @default.
- W2078113353 cites W2035422545 @default.
- W2078113353 cites W2037723379 @default.
- W2078113353 cites W2050918242 @default.
- W2078113353 cites W2052723831 @default.
- W2078113353 cites W2054151200 @default.
- W2078113353 cites W2056123267 @default.
- W2078113353 cites W2058528119 @default.
- W2078113353 cites W2059532513 @default.
- W2078113353 cites W2065422772 @default.
- W2078113353 cites W2068742932 @default.
- W2078113353 cites W2069022895 @default.
- W2078113353 cites W2072303535 @default.
- W2078113353 cites W2076087769 @default.
- W2078113353 cites W2076946784 @default.
- W2078113353 cites W2083289888 @default.
- W2078113353 cites W2097090948 @default.
- W2078113353 cites W2099002558 @default.
- W2078113353 cites W2101325866 @default.
- W2078113353 cites W2105505995 @default.
- W2078113353 cites W2110873651 @default.
- W2078113353 cites W2112160006 @default.
- W2078113353 cites W2126081885 @default.
- W2078113353 cites W2129448282 @default.
- W2078113353 cites W2132428980 @default.
- W2078113353 cites W2136570112 @default.
- W2078113353 cites W2143777308 @default.
- W2078113353 cites W2144192475 @default.
- W2078113353 cites W2147373137 @default.
- W2078113353 cites W2150080189 @default.
- W2078113353 cites W2161282017 @default.
- W2078113353 cites W2307290500 @default.
- W2078113353 cites W3026371142 @default.
- W2078113353 doi "https://doi.org/10.1242/dev.02001" @default.
- W2078113353 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6986394" @default.
- W2078113353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16120640" @default.
- W2078113353 hasPublicationYear "2005" @default.
- W2078113353 type Work @default.
- W2078113353 sameAs 2078113353 @default.
- W2078113353 citedByCount "85" @default.
- W2078113353 countsByYear W20781133532012 @default.
- W2078113353 countsByYear W20781133532013 @default.
- W2078113353 countsByYear W20781133532014 @default.
- W2078113353 countsByYear W20781133532015 @default.
- W2078113353 countsByYear W20781133532016 @default.
- W2078113353 countsByYear W20781133532018 @default.
- W2078113353 countsByYear W20781133532019 @default.
- W2078113353 countsByYear W20781133532020 @default.
- W2078113353 countsByYear W20781133532021 @default.
- W2078113353 countsByYear W20781133532022 @default.
- W2078113353 countsByYear W20781133532023 @default.
- W2078113353 crossrefType "journal-article" @default.
- W2078113353 hasAuthorship W2078113353A5021331883 @default.
- W2078113353 hasAuthorship W2078113353A5027287933 @default.
- W2078113353 hasAuthorship W2078113353A5047977465 @default.
- W2078113353 hasAuthorship W2078113353A5050911555 @default.
- W2078113353 hasAuthorship W2078113353A5058427531 @default.
- W2078113353 hasBestOaLocation W20781133531 @default.
- W2078113353 hasConcept C102309675 @default.
- W2078113353 hasConcept C104317684 @default.
- W2078113353 hasConcept C105702510 @default.
- W2078113353 hasConcept C143065580 @default.
- W2078113353 hasConcept C145103041 @default.
- W2078113353 hasConcept C170493617 @default.
- W2078113353 hasConcept C196843134 @default.