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- W2078114300 abstract "The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age‐related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin‐like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD." @default.
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- W2078114300 date "2007-02-02" @default.
- W2078114300 modified "2023-10-13" @default.
- W2078114300 title "Transformation of the proteasome with age-related macular degeneration" @default.
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- W2078114300 doi "https://doi.org/10.1016/j.febslet.2007.01.061" @default.
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