Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078114432> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2078114432 endingPage "51" @default.
- W2078114432 startingPage "42" @default.
- W2078114432 abstract "The 3D hydrodynamics and shear rates distributions within the United States Pharmacopeia Apparatus 2 have been investigated in this paper. With the help of a CFD package, several geometric modifications to the device were evaluated in this study. Specially, we examine the influence of impeller clearance, blade diameter, shape of the vessel base and shape of the lower part of blade. Increasing the impeller clearance was observed to exacerbate the heterogeneity in shear and would likely result in greater variability in dissolution measurements. Use of moderate blade diameter and dished bottom were observed to reduce shear heterogeneity in the regions where tablets are most likely to visit during testing. The comparative analysis shows better reproducibility and accelerated dissolution rates with the modified vessel shape, the dished bottom can enhance mixing near the vessel base when compared with the flat bottom. Increasing length of the lower edge of the paddle was observed to generate high radial pumping and to enlarge the dead zone located at the center of the vessel base." @default.
- W2078114432 created "2016-06-24" @default.
- W2078114432 creator A5032022827 @default.
- W2078114432 creator A5056616099 @default.
- W2078114432 date "2013-08-01" @default.
- W2078114432 modified "2023-10-16" @default.
- W2078114432 title "3D hydrodynamics and shear rates’ variability in the United States Pharmacopeia Paddle Dissolution Apparatus" @default.
- W2078114432 cites W181212721 @default.
- W2078114432 cites W1970998758 @default.
- W2078114432 cites W1971842560 @default.
- W2078114432 cites W1975007658 @default.
- W2078114432 cites W1986642287 @default.
- W2078114432 cites W1986998634 @default.
- W2078114432 cites W1992207555 @default.
- W2078114432 cites W2004682842 @default.
- W2078114432 cites W2010209385 @default.
- W2078114432 cites W2014307488 @default.
- W2078114432 cites W2037524373 @default.
- W2078114432 cites W2039467822 @default.
- W2078114432 cites W2045569324 @default.
- W2078114432 cites W2048786871 @default.
- W2078114432 cites W2058406640 @default.
- W2078114432 cites W2060816850 @default.
- W2078114432 cites W2079487493 @default.
- W2078114432 cites W2099609156 @default.
- W2078114432 cites W2106177934 @default.
- W2078114432 cites W2111431523 @default.
- W2078114432 cites W2166338073 @default.
- W2078114432 cites W2326532832 @default.
- W2078114432 doi "https://doi.org/10.1016/j.ijpharm.2013.04.049" @default.
- W2078114432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23680733" @default.
- W2078114432 hasPublicationYear "2013" @default.
- W2078114432 type Work @default.
- W2078114432 sameAs 2078114432 @default.
- W2078114432 citedByCount "19" @default.
- W2078114432 countsByYear W20781144322015 @default.
- W2078114432 countsByYear W20781144322016 @default.
- W2078114432 countsByYear W20781144322017 @default.
- W2078114432 countsByYear W20781144322018 @default.
- W2078114432 countsByYear W20781144322020 @default.
- W2078114432 countsByYear W20781144322021 @default.
- W2078114432 countsByYear W20781144322023 @default.
- W2078114432 crossrefType "journal-article" @default.
- W2078114432 hasAuthorship W2078114432A5032022827 @default.
- W2078114432 hasAuthorship W2078114432A5056616099 @default.
- W2078114432 hasConcept C121332964 @default.
- W2078114432 hasConcept C138777275 @default.
- W2078114432 hasConcept C147789679 @default.
- W2078114432 hasConcept C153005164 @default.
- W2078114432 hasConcept C159985019 @default.
- W2078114432 hasConcept C165150422 @default.
- W2078114432 hasConcept C185592680 @default.
- W2078114432 hasConcept C192562407 @default.
- W2078114432 hasConcept C43617362 @default.
- W2078114432 hasConcept C57879066 @default.
- W2078114432 hasConcept C62520636 @default.
- W2078114432 hasConcept C88380143 @default.
- W2078114432 hasConcept C96035792 @default.
- W2078114432 hasConcept C9893847 @default.
- W2078114432 hasConceptScore W2078114432C121332964 @default.
- W2078114432 hasConceptScore W2078114432C138777275 @default.
- W2078114432 hasConceptScore W2078114432C147789679 @default.
- W2078114432 hasConceptScore W2078114432C153005164 @default.
- W2078114432 hasConceptScore W2078114432C159985019 @default.
- W2078114432 hasConceptScore W2078114432C165150422 @default.
- W2078114432 hasConceptScore W2078114432C185592680 @default.
- W2078114432 hasConceptScore W2078114432C192562407 @default.
- W2078114432 hasConceptScore W2078114432C43617362 @default.
- W2078114432 hasConceptScore W2078114432C57879066 @default.
- W2078114432 hasConceptScore W2078114432C62520636 @default.
- W2078114432 hasConceptScore W2078114432C88380143 @default.
- W2078114432 hasConceptScore W2078114432C96035792 @default.
- W2078114432 hasConceptScore W2078114432C9893847 @default.
- W2078114432 hasIssue "1-2" @default.
- W2078114432 hasLocation W20781144321 @default.
- W2078114432 hasLocation W20781144322 @default.
- W2078114432 hasOpenAccess W2078114432 @default.
- W2078114432 hasPrimaryLocation W20781144321 @default.
- W2078114432 hasRelatedWork W133745085 @default.
- W2078114432 hasRelatedWork W1933539706 @default.
- W2078114432 hasRelatedWork W1992451173 @default.
- W2078114432 hasRelatedWork W2017605127 @default.
- W2078114432 hasRelatedWork W2089901852 @default.
- W2078114432 hasRelatedWork W2092998013 @default.
- W2078114432 hasRelatedWork W2350158879 @default.
- W2078114432 hasRelatedWork W2359201683 @default.
- W2078114432 hasRelatedWork W2378915318 @default.
- W2078114432 hasRelatedWork W2794909495 @default.
- W2078114432 hasVolume "452" @default.
- W2078114432 isParatext "false" @default.
- W2078114432 isRetracted "false" @default.
- W2078114432 magId "2078114432" @default.
- W2078114432 workType "article" @default.