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- W2078114798 abstract "Small-molecule microarrays are often limited by the requirement for each compound undergoing immobilization to contain a common functional group or by the need to prepare glass slides containing photo-reactive groups. Herein, we present a generic strategy that allows any compound library to be immobilized. This was achieved by printing a fluorous-tagged photo-reactive 3-aryl-3-trifluoromethyldiazirine, which undergoes non-selective insertion into compounds following UV-activation, onto fluorous-functionalized glass slides. The arrays could be reused following aqueous stripping and re-assessment of the compounds with the same protein or another target of interest." @default.
- W2078114798 created "2016-06-24" @default.
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- W2078114798 date "2011-12-01" @default.
- W2078114798 modified "2023-09-23" @default.
- W2078114798 title "A generic small-molecule microarray immobilization strategy" @default.
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- W2078114798 doi "https://doi.org/10.1016/j.tetlet.2011.10.055" @default.
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