FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078116391> ?p ?o ?g. }

• W2078116391 endingPage "41744" @default.
• W2078116391 startingPage "41736" @default.
• W2078116391 abstract "In a proteomic search for heparan sulfate-binding proteins on monocytes, we identified HMGB1 (high mobility group protein B1). The extracellular role of HMGB1 as a cytokine has been studied intensively and shown to be important as a danger-associated molecular pattern protein. Here, we report that the activity of HMGB1 depends on heparan sulfate. Binding and competition studies demonstrate that HMGB1 interacts with CHO and endothelial cell heparan sulfate. By site-directed mutagenesis, we identified a loop region that connects the A-box and B-box domains of HMGB1 as responsible for heparan sulfate binding. HMGB1-induced Erk1/2 and p38 phosphorylation is abolished when endothelial heparan sulfate is removed or blocked pharmacologically, resulting in decreased HMGB1-induced endothelial sprouting. However, mutated HMGB1 that lacks the heparan sulfate-binding site retained its signaling activity. We show the major receptor for HMGB1, receptor for advanced glycation end products (RAGE), also binds to heparan sulfate and that RAGE and heparan sulfate forms a complex. Our data establishes that the functional receptor for HMGB1 consists of a complex of RAGE and cell surface heparan sulfate." @default.
• W2078116391 created "2016-06-24" @default.
• W2078116391 creator A5013197657 @default.
• W2078116391 creator A5019205897 @default.
• W2078116391 creator A5044617581 @default.
• W2078116391 creator A5067976238 @default.
• W2078116391 date "2011-12-01" @default.
• W2078116391 modified "2023-10-13" @default.
• W2078116391 title "Heparan Sulfate Is Essential for High Mobility Group Protein 1 (HMGB1) Signaling by the Receptor for Advanced Glycation End Products (RAGE)" @default.
• W2078116391 cites W1518484130 @default.
• W2078116391 cites W1525114741 @default.
• W2078116391 cites W1551118958 @default.
• W2078116391 cites W168035116 @default.
• W2078116391 cites W1919666680 @default.
• W2078116391 cites W1965497701 @default.
• W2078116391 cites W1971246306 @default.
• W2078116391 cites W1974873948 @default.
• W2078116391 cites W1976389947 @default.
• W2078116391 cites W1982539363 @default.
• W2078116391 cites W1997125262 @default.
• W2078116391 cites W2006641366 @default.
• W2078116391 cites W2009889319 @default.
• W2078116391 cites W2012053447 @default.
• W2078116391 cites W2018653121 @default.
• W2078116391 cites W2022064271 @default.
• W2078116391 cites W2030155901 @default.
• W2078116391 cites W2036607811 @default.
• W2078116391 cites W2054241501 @default.
• W2078116391 cites W2055132644 @default.
• W2078116391 cites W2059217150 @default.
• W2078116391 cites W2059763409 @default.
• W2078116391 cites W2061353036 @default.
• W2078116391 cites W2061814831 @default.
• W2078116391 cites W2076999225 @default.
• W2078116391 cites W2080174546 @default.
• W2078116391 cites W2090438409 @default.
• W2078116391 cites W2097391811 @default.
• W2078116391 cites W2099762218 @default.
• W2078116391 cites W2106949373 @default.
• W2078116391 cites W2118046722 @default.
• W2078116391 cites W2122965729 @default.
• W2078116391 cites W2126039250 @default.
• W2078116391 cites W2130389715 @default.
• W2078116391 cites W2132014421 @default.
• W2078116391 cites W2149171717 @default.
• W2078116391 cites W2156700198 @default.
• W2078116391 cites W2162034771 @default.
• W2078116391 cites W2164463504 @default.
• W2078116391 doi "https://doi.org/10.1074/jbc.m111.299685" @default.
• W2078116391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3308882" @default.
• W2078116391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21990362" @default.
• W2078116391 hasPublicationYear "2011" @default.
• W2078116391 type Work @default.
• W2078116391 sameAs 2078116391 @default.
• W2078116391 citedByCount "76" @default.
• W2078116391 countsByYear W20781163912012 @default.
• W2078116391 countsByYear W20781163912013 @default.
• W2078116391 countsByYear W20781163912014 @default.
• W2078116391 countsByYear W20781163912015 @default.
• W2078116391 countsByYear W20781163912016 @default.
• W2078116391 countsByYear W20781163912017 @default.
• W2078116391 countsByYear W20781163912018 @default.
• W2078116391 countsByYear W20781163912019 @default.
• W2078116391 countsByYear W20781163912020 @default.
• W2078116391 countsByYear W20781163912021 @default.
• W2078116391 countsByYear W20781163912022 @default.
• W2078116391 countsByYear W20781163912023 @default.
• W2078116391 crossrefType "journal-article" @default.
• W2078116391 hasAuthorship W2078116391A5013197657 @default.
• W2078116391 hasAuthorship W2078116391A5019205897 @default.
• W2078116391 hasAuthorship W2078116391A5044617581 @default.
• W2078116391 hasAuthorship W2078116391A5067976238 @default.
• W2078116391 hasBestOaLocation W20781163911 @default.
• W2078116391 hasConcept C147990577 @default.
• W2078116391 hasConcept C1491633281 @default.
• W2078116391 hasConcept C169760540 @default.
• W2078116391 hasConcept C170493617 @default.
• W2078116391 hasConcept C185592680 @default.
• W2078116391 hasConcept C2778041096 @default.
• W2078116391 hasConcept C2778857457 @default.
• W2078116391 hasConcept C2780545709 @default.
• W2078116391 hasConcept C55493867 @default.
• W2078116391 hasConcept C86803240 @default.
• W2078116391 hasConcept C95444343 @default.
• W2078116391 hasConceptScore W2078116391C147990577 @default.
• W2078116391 hasConceptScore W2078116391C1491633281 @default.
• W2078116391 hasConceptScore W2078116391C169760540 @default.
• W2078116391 hasConceptScore W2078116391C170493617 @default.
• W2078116391 hasConceptScore W2078116391C185592680 @default.
• W2078116391 hasConceptScore W2078116391C2778041096 @default.
• W2078116391 hasConceptScore W2078116391C2778857457 @default.
• W2078116391 hasConceptScore W2078116391C2780545709 @default.
• W2078116391 hasConceptScore W2078116391C55493867 @default.
• W2078116391 hasConceptScore W2078116391C86803240 @default.
• W2078116391 hasConceptScore W2078116391C95444343 @default.
• W2078116391 hasIssue "48" @default.
• W2078116391 hasLocation W20781163911 @default.
• W2078116391 hasLocation W20781163912 @default.

• next